Izonsteride

Izonsteride
Clinical data
Other names	LY-320,236
Routes of; administration	By mouth
ATC code	None;
Identifiers
	IUPAC name (4aR,10bR)-8-[(4-ethyl-1,3-benzothiazol-2-yl)sulfanyl]-4,10b-dimethyl-1,4,4a,5,6,10b-hexahydrobenzo[f]quinolin-3(2H)-one;
CAS Number	176975-26-1;
PubChem CID	172988;
ChemSpider	151061;
UNII	A5E8C36F34;
CompTox Dashboard (EPA)	DTXSID80170230 ;
Chemical and physical data
Formula	C24H26N2OS2
Molar mass	422.61 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C4N(C)[C@@H]5CCc3cc(Sc1nc2c(cccc2s1)CC)ccc3[C@@]5(C)CC4;

Other namesLY-320,236

Routes of
administrationBy mouth

ATC code

None

CAS Number

176975-26-1

Izonsteride (developmental code name LY-320,236) is a selective inhibitor of the 5α-reductase, with dual effects on both the type I and type II isoforms of the enzyme.^[1] It was under development by Eli Lilly and Company and Fujisawa for the treatment of benign prostatic hyperplasia but was never marketed.^[2]^[3] Izonsteride may also be useful in the treatment of androgenic alopecia.^[1]

[1]

[2]

[3]

v t e Drugs used in benign prostatic hyperplasia (G04C)
5α-Reductase inhibitors	Dutasteride Epristeride Finasteride (+tadalafil)
Alpha-1 blockers	Alfuzosin Doxazosin Silodosin Tamsulosin Terazosin
Steroidal antiandrogens	Allylestrenol Delmadinone acetate Gestonorone caproate Osaterone acetate Oxendolone
Herbal products	Pygeum africanum Saw palmetto extract
Others	Mepartricin

v t e Other dermatological preparations (D11)
Anti-seborrheics	Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide) Ciclopirox olamine (ciclopirox) Climbazole Clotrimazole Ketoconazole Miconazole Piroctone olamine Selenium disulfide (selenium sulfide) Xenysalate Zinc pyrithione (pyrithione zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea (urea-containing cream) Lithium salts Lithium gluconate Lithium succinate Topical corticosteroids (e.g., hydrocortisone)
Skin lightening	Hydroquinone Mequinol Monobenzone
Skin darkening	Afamelanotide Melanotan II
Anti-inflammatories	Alitretinoin Gamolenic acid Oxaceprol Pimecrolimus Tacrolimus Topical corticosteroids (e.g., hydrocortisone)
Alopecia treatments	5α-Reductase inhibitors Alfatradiol Dutasteride Finasteride Saw palmetto extract Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Topilutamide (fluridil) Potassium channel openers Minoxidil Others Minoxidil/finasteride Nepidermin PP405 Ritlecitinib
Hair growth inhibitors	5α-Reductase inhibitors Dutasteride Finasteride Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Eflornithine
Others	Abrocitinib Aminobenzoate potassium Androgens (e.g., testosterone) Atinvicitinib Benzoylperoxide Brimonidine Caffeine Calcium gluconate Collagen Crisaborole Cromoglicic acid Delgocitinib Deoxycholic acid Diclofenac Dupilumab Estrogens (e.g., estradiol) Glycopyrronium bromide Glycopyrronium tosylate Hyaluronic acid Hydrogen peroxide Ilunocitinib Ivermectin Lebrikizumab Lokivetmab Magnesium sulfate Metandienone Nemolizumab Oclacitinib Oxymetazoline Povidone-iodine Pregnenolone acetate Progestogens (e.g., progesterone) Ruxolitinib Sofpironium bromide Tiratricol Tralokinumab

Izonsteride

Synthesis

See also

References

Related Articles

Clinical data

Other names	LY-320,236
Routes of administration	By mouth
ATC code	None
Identifiers
IUPAC name (4aR,10bR)-8-[(4-ethyl-1,3-benzothiazol-2-yl)sulfanyl]-4,10b-dimethyl-1,4,4a,5,6,10b-hexahydrobenzo[f]quinolin-3(2H)-one
CAS Number	176975-26-1
PubChem CID	172988
ChemSpider	151061
UNII	A5E8C36F34
CompTox Dashboard (EPA)	DTXSID80170230
Chemical and physical data
Formula	C₂₄H₂₆N₂OS₂
Molar mass	422.61 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C4N(C)[C@@H]5CCc3cc(Sc1nc2c(cccc2s1)CC)ccc3[C@@]5(C)CC4