Sofpironium bromide

Sofpironium bromide, sold under the brand names Ecclock and Sofdra among others, is a medication used to treat hyperhidrosis (excessive sweating).^[1] Sofpironium bromide is an anticholinergic agent that is applied to the skin.^[1]

Trade namesEcclock, Sofdra, others

Other namesBBI-4000, BBI 4000

AHFS/Drugs.comMonograph

MedlinePlusa624052

Quick facts Clinical data, Trade names ...

Sofpironium bromide

Clinical data
Trade names	Ecclock, Sofdra, others
Other names	BBI-4000, BBI 4000
AHFS/Drugs.com	Monograph
MedlinePlus	a624052
License data	US DailyMed: Sofpironium bromide
Routes of administration	Topical
Drug class	Anticholinergic
ATC code	D11AA02 (WHO)
Legal status
Legal status	US: ℞-only[1] JP: Rx-only
Identifiers
IUPAC name [(3R)-1-(2-Ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate bromide
CAS Number	1628106-94-4
PubChem CID	86301316
DrugBank	DB19325
ChemSpider	52085312
UNII	7B2Y1932XU
KEGG	D10989
ChEMBL	ChEMBL3707223
Chemical and physical data
Formula	C22H32BrNO5
Molar mass	470.404 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCOC(=O)C[N+]1(CC[C@H](C1)OC(=O)[C@@](C2CCCC2)(C3=CC=CC=C3)O)C.[Br-]
InChI InChI=1S/C22H32NO5.BrH/c1-3-27-20(24)16-23(2)14-13-19(15-23)28-21(25)22(26,18-11-7-8-12-18)17-9-5-4-6-10-17;/h4-6,9-10,18-19,26H,3,7-8,11-16H2,1-2H3;1H/q+1;/p-1/t19-,22+,23?;/m1./s1 Key:FIAFMTCUJCWADZ-JOFREBOKSA-M

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It was approved for medical use in Japan in 2020,^[2] and in the United States in June 2024.^[1][3][4][5]