KCNK3

Potassium channel subfamily K member 3 is a protein that in humans is encoded by the KCNK3 gene.^[5][6][7][8]

PDBOrtholog search: PDBe RCSB

AliasesKCNK3, K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1, potassium two pore domain channel subfamily K member 3, TASK1

External IDsOMIM: 603220; MGI: 1100509; HomoloGene: 1692; GeneCards: KCNK3; OMA:KCNK3 - orthologs

Chr.Chromosome 2 (human)^[1]

Quick facts Available structures, PDB ...

KCNK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 6RV2, 6RV3, 6RV4
Identifiers
Aliases	KCNK3, K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1, potassium two pore domain channel subfamily K member 3, TASK1
External IDs	OMIM: 603220; MGI: 1100509; HomoloGene: 1692; GeneCards: KCNK3; OMA:KCNK3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 26,692,722 bp[1] End 26,733,420 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B1|5 16.68 cM Start 30,745,514 bp[2] End 30,782,615 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left adrenal gland adrenal cortex left adrenal cortex right adrenal cortex beta cell lower lobe of lung right lung paraflocculus of cerebellum pons upper lobe of lung Top expressed in adrenal gland lobe of prostate brown adipose tissue myocardium of ventricle right ventricle cerebellar cortex facial motor nucleus lobe of cerebellum cardiac muscles tunica adventitia of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function S100 protein binding potassium channel activity protein homodimerization activity open rectifier potassium channel activity potassium ion leak channel activity ion channel activity protein heterodimerization activity growth factor activity protein C-terminus binding protein binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular space Biological process cochlea development ion transport cellular response to zinc ion potassium ion transport ion transmembrane transport brain development cardiac conduction potassium ion transmembrane transport cellular response to hypoxia negative regulation of cytosolic calcium ion concentration chemical synaptic transmission stabilization of membrane potential regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3777 16527 Ensembl ENSG00000171303 ENSMUSG00000049265 UniProt O14649 O35111 RefSeq (mRNA) NM_002246 NM_010608 RefSeq (protein) NP_002237 NP_034738 Location (UCSC) Chr 2: 26.69 – 26.73 Mb Chr 5: 30.75 – 30.78 Mb PubMed search [3] [4]
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This gene encodes K_2P3.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P3.1 is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.^[8]