KMT2C

KMT2C
Identifiers
Aliases	KMT2C, HALR, MLL3, lysine methyltransferase 2C, KLEFS2
External IDs	OMIM: 606833; MGI: 2444959; GeneCards: KMT2C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YSM, 2YUK, 3UVL, 4ERY, 5F59, 5F6K
Enzyme activity
Gene location (Human)
Chr.	Chromosome 7 (human)
End	152,436,644 bp
RNA expression pattern
	Top expressed in
	oocyte; ; caput epididymis; ; skin of arm; ; pancreatic epithelial cell; ; corpus epididymis; ; cardiac muscle tissue of right atrium; ; Achilles tendon; ; sural nerve; ; bone marrow cell; ; seminal vesicula;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	methyltransferase activity; transferase activity; DNA binding; protein binding; histone methyltransferase activity (H3-K4 specific); metal ion binding; acyltransferase activity; histone-lysine N-methyltransferase activity; RNA binding; transcription coactivator activity; histone binding;
Cellular component	MLL3/4 complex; nucleus; nucleoplasm; histone methyltransferase complex;
Biological process	histone lysine methylation; methylation; regulation of transcription, DNA-templated; transcription, DNA-templated; histone H3-K4 methylation; regulation of megakaryocyte differentiation; chromatin organization; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	58508
	231051
	ENSG00000055609
	n/a
	Q8NEZ4
	Q8BRH4
	NM_021230; NM_170606
	NM_001081383; NM_177283
	NP_733751
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine N-methyltransferase 2C (KMT2C) also known as myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3) is an enzyme that in humans is encoded by the KMT2C gene.^[4]^[5]