LDOC1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Protein LDOC1 is a protein that in humans is encoded by the LDOC1 gene.[5][6][7][8]
AliasesLDOC1, BCUR1, Mar7, Mart7, leucine zipper, down-regulated in cancer 1, regulator of NFKB signaling, SIRH7, RTL7, LDOC1 regulator of NFKB signaling
External IDsOMIM: 300402; MGI: 2685212; HomoloGene: 32153; GeneCards: LDOC1; OMA:LDOC1 - orthologs
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| Aliases | LDOC1, BCUR1, Mar7, Mart7, leucine zipper, down-regulated in cancer 1, regulator of NFKB signaling, SIRH7, RTL7, LDOC1 regulator of NFKB signaling | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 300402; MGI: 2685212; HomoloGene: 32153; GeneCards: LDOC1; OMA:LDOC1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.[8]
