LTBP2

Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene.^[5][6]

AliasesLTBP2, C14orf141, GLC3D, LTBP3, MSPKA, MSTP031, WMS3, latent transforming growth factor beta binding protein 2

External IDsOMIM: 602091; MGI: 99502; HomoloGene: 369; GeneCards: LTBP2; OMA:LTBP2 - orthologs

Chr.Chromosome 14 (human)^[1]

End74,612,378 bp^[1]

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LTBP2
Identifiers
Aliases	LTBP2, C14orf141, GLC3D, LTBP3, MSPKA, MSTP031, WMS3, latent transforming growth factor beta binding protein 2
External IDs	OMIM: 602091; MGI: 99502; HomoloGene: 369; GeneCards: LTBP2; OMA:LTBP2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 74,498,183 bp[1] End 74,612,378 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 D1 Start 84,829,986 bp[2] End 84,923,306 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta ascending aorta stromal cell of endometrium right coronary artery tendon of biceps brachii saphenous vein pericardium left coronary artery popliteal artery tibial arteries Top expressed in aortic valve ascending aorta rib stroma of bone marrow vestibular membrane of cochlear duct external carotid artery left lung lobe brown adipose tissue ciliary body calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding heparin binding protein binding growth factor binding extracellular matrix structural constituent microfibril binding Cellular component extracellular matrix extracellular exosome intracellular anatomical structure extracellular space extracellular region collagen-containing extracellular matrix Biological process protein targeting transforming growth factor beta receptor signaling pathway protein secretion supramolecular fiber organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4053 16997 Ensembl ENSG00000119681 ENSMUSG00000002020 UniProt Q14767 O08999 RefSeq (mRNA) NM_000428 NM_013589 NM_001370743 RefSeq (protein) NP_000419 NP_038617 NP_001357672 Location (UCSC) Chr 14: 74.5 – 74.61 Mb Chr 12: 84.83 – 84.92 Mb PubMed search [3] [4]
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The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins.

It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.^[6]