List of Nurse Jackie episodes

Veteran emergency room nurse Jackie Peyton navigates the traffic of Manhattan's All Saints Hospital while hiding a subtle drug addiction and making tough and sometimes unethical decisions for the "good" of her patients. Clashing with cocky young surgeon Dr. Fitch "Coop" Cooper and begrudgingly training naïve and perky new nurse Zoey, Jackie maintains a romantic relationship with pharmacist Eddie to assure her ready access to prescription medication. When Coop's negligence causes a bike messenger to die, Jackie tries to make good of the patient's senseless death by forging an organ donor authorization for him. Jackie also punishes a violent sociopath with diplomatic immunity by flushing his severed ear down the toilet. At the end of her shift, Jackie returns home, where it is revealed that she has a husband, Kevin, and two young daughters.

Jackie brings Sweet 'n All packets laced with ground-up Percocet to get her through the day, but one of the packets is accidentally taken by the stern hospital administrator Gloria Akalitus. Zoey discovers the resurfaced flushed ear and gives it to Gloria. Upon being confronted, Jackie shifts the blame towards Zoey. All Saints nurse Mohammed "Momo" De La Cruz bonds with a patient whose oxygen tank exploded when she lit a cigarette. Jackie and Coop treat a child in a skateboard accident who was not wearing a helmet; Jackie is forced to swallow her pride and tell Coop that he had been right about diagnosing a patient's unlikely aneurysm.

Jackie and Kevin discuss their eldest daughter Grace's mounting anxiety, after which Jackie confides her concerns to her best friend Dr. Eleanor O'Hara. Jackie treats a dying man who refuses further treatment, instead choosing to treat his heart failure with chicken soup; Jackie allows the man to pass peacefully in the hospital with his wife, to Gloria's dismay. A couple from Ohio comes into the ER for a possible pregnancy, but Jackie discovers that the wife is actually going through withdrawal from Vicodin. Meanwhile, Zoey tries to work up the courage to ask for her new stethoscope back after Eleanor takes it, while Eddie faces the possibility of being replaced by an automated Pyxis dispensary.

Jackie and Kevin attend a school meeting to discuss Grace's psychological development, but Jackie grows defensive when the school nurse suggests prescribing anti-anxiety medication for Grace. Jackie, Momo and Eleanor treat an unconscious twin boy who has fallen off playground equipment; Momo is affected by the patient, lamenting the loss of his own twin brother, while Eleanor struggles to deal with the gushing, innocent gratitude of her young patient's twin brother after she saves the boy's life. Jackie buys a second cell phone after receiving multiple romantic texts from Eddie. Zoey, lamenting a day of "unexciting" cases being assigned to her, experiences her first patient death while treating an elderly woman with a DNR.

Jackie treats a ten-year-old girl caring for her lupus-stricken mother, and tries to buck the system to assist the girl when Gloria suggests calling social services. Male bonding between Eddie and Coop puts a damper on Jackie's usual mid-shift tryst in the pharmacy back-room, while Zoey fills in for Jackie as Eleanor's dinner date. Momo spends the night simultaneously deflecting the advances of diabetic nurse Thor, while enjoying the fringe benefits of Thor's crush on him. Gloria, exasperated by the staff's seeming-disregard for order and professionalism, accidentally tasers herself while trying to retrieve an unattended taser lying in the hallway.

Jackie tries to convince Grace to transfer to private school. Paula, a fellow nurse and old friend of Jackie's, checks into the hospital with terminal lung cancer. Paula refuses to check into hospice and asks Jackie to help end her life; Jackie does so by secretly giving her morphine. Jackie is stunned when Paula admits that Eddie used to supply her with Percocet. Meanwhile, Coop's two mothers, Leslie and Maureen, arrive at the ER to admit Maureen for a gallbladder attack. Coop confides to Leslie about his struggles with Tourette's as a child, and admits that he loved Leslie more growing up; Leslie counters that she was the "fun mom" because Maureen deliberately wanted them to bond.

The staff at All Saints are forced to deal with a mentally ill man who shouts from his apartment window across the street and refers to himself as God. Eddie surprises Jackie with a bracelet for their first anniversary, but ends up giving it to Coop when she reacts poorly to the gift. A man is admitted to the ER with a steak knife in his chest, after an attack by the ex-husband of a woman he was dating for the first time. Eleanor has a personal crisis with her family, leading Jackie to invite her to spend the night at her house. Gloria takes charge of a foundling abandoned at the nurses' station and tries to figure out who the baby belongs to.

When the emergency room is four nurses short, Gloria introduces Jackie to Sam, a dimwitted temp nurse. Zoey correctly deduces that Sam is abusing drugs and informs Jackie, who confronts Sam and asks him to leave; she is stunned when he calls her out on her hypocrisy. Coop treats an older woman with a head wound, who expresses interest in setting him up with her daughter Melissa. Gloria still has the foundling infant left at the hospital. Grace experiences a panic attack at her new private school and calls Jackie, who inadvertently reveals to Coop that she has a child while answering the call. Coop later reveals the news to Eddie, who confronts Jackie; she apologizes to Eddie for not telling him about her daughter, but does not reveal that she is married.

While admitting a homeless patient she has treated before, Jackie experiences a drug-induced nosebleed. Jackie criticizes Zoey when the homeless patient undergoes a foot amputation, but Zoey responds that Jackie had previously instructed her to underserve the patient during an earlier visit. Jackie denies this and later rips out a page out of Zoey's notebook that supports Zoey's account. Gloria considers adopting the foundling infant, but reluctantly gives the infant back to the teenage couple who have come forward to reclaim their child. Jackie is upset when Eleanor reveals that she had told her sister in Paris about Jackie's affair with Eddie. Jackie and Coop treat a brain dead patient who was in a car accident, and Jackie forges an organ donation form in Coop's name while he is preoccupied.

Jackie begins mother-daughter dance lessons with Grace. Returning to work, Jackie is unable to remove her wedding ring from her finger, and she asks Eleanor to help cut the ring off with a bone saw. A young man is brought into the ER with cardiac arrest, and Jackie uses his cell phone to inform his girlfriend about his death. Coop threatens to report Jackie over the fake organ donor card, but Jackie manipulates Coop by kissing him to keep him distracted. Zoey accidentally walks in on Jackie and Eddie having sex in the pharmacy back-room. Jackie deliberately breaks her finger with a hammer in order to cover up the broken wedding ring to Kevin.

Jackie gets tossed out of the mother-daughter dance lessons after clashing with Ginny, a mother whom she knew from her high school days. Coop has begun a relationship with Melissa, but ultimately decides to break up with her, having fallen in love with Jackie after their kiss. Momo treats a young man with a spider trapped in his ear. Neil Nutterman, a well-known film critic, is admitted for a broken arm, but Zoey administers the wrong dose of a painkiller, which causes Neil to fall into a coma. Eddie is replaced by the Pill-O-Matix, an automatic pill dispensing machine, and he gives Jackie 80 milligram tabs of Oxycontin as a parting gift, expressing an interest in pursuing their relationship further. At the end of the episode, Jackie heads to Kevin's bar and tenderly embraces her family; a devastated Eddie is revealed to have been watching from the bar window.

Kevin invites Jackie to a midnight rendezvous in order to give her a new wedding ring. Following Neil's coma incident, Gloria attempts to launch an investigation and tries to get an official statement from Jackie and Zoey, but her plans are derailed after she gets stuck inside the hospital elevator. Neil eventually wakes up from his coma, but Zoey discovers that his tastes have radically changed. Eleanor arranges to secretly admit her dead mother into the hospital for a post mortem, and asks Jackie to be there with her for comfort. Eddie arrives at Kevin's bar and deliberately constructs a friendship with Kevin, asking him questions about his wife and family. Later, Eddie arrives at All Saints and drunkenly confronts the staff before informing Jackie that he met Kevin. Stunned and distraught, Jackie orders three vials of morphine from the Pill-O-Matix and downs them in an empty examination room.

Three months later, Jackie tries to reconnect with her family while continuing to ignore Eddie's calls. At the hospital, Gloria is concerned with the growing disappearance of drugs and asks Jackie to train the staff on how to properly use the Pill-O-Matix. Jackie and Coop clash while treating a deaf woman who has lost her fingers, after which Coop turns to Gloria to file a formal complaint against her for insubordination. Eleanor, having recently acquired her mother's estate, expresses interest in helping Jackie set up a college fund for Grace and Fiona. Jackie is dismayed to learn that Gloria has re-hired Sam, who has successfully completed a drug rehabilitation program, as a registered nurse. In an attempt to gain Jackie's attention, Eddie purposely overdoses on Xanax and is admitted into the ER.

Mourning her mother's death, Eleanor shows up after a night of clubbing, and Jackie covers for her while she comes down from Ecstasy. Worried about Grace's escalating anxiety, Jackie surreptitiously asks Gloria for a pediatric psych referral. Eddie visits the bar and continues his friendship with Kevin, while Zoey treats God and talks him through an identity crisis. Jackie drops a package of pills in front of Sam, who presses her about the hospital's policy on lost drugs. Jackie is irritated by Coop, who has taken to Twitter as a way to vent. While treating a young boy with a serious respiratory problem, Jackie cuts through red tape to speed up the boy's diagnosis, and sends the family away after receiving the boy's preliminary results. Later, Coop berates Jackie for her actions, as the boy's final results reveal that he has cystic fibrosis.

Grace has a playdate with Ginny's daughter Kaitlyn, who catches Jackie snorting drugs in the basement. Jackie approaches Kevin about Eleanor's offer to set up a college fund for Grace and Fiona, but Kevin refuses to take the money. Coop makes New York Magazine's Top 25 Doctors list, giving him reason to gloat and flabbergasting most of the staff, particularly Eleanor and Gloria. Coop also visits Eddie, who has recovered from his overdose and now works at a local pharmacy. The staff treat a man whose testicles have migrated after being mauled by a Great Dane, as well as a patient suffering second-degree burns from an exploding cell phone. After her shift, Jackie returns home and discovers that Kevin has invited Eddie over.

Following Eddie's intrusion into her home life, Jackie visits Eddie at his pharmacy to lambast him, but he expresses interest in resuming their relationship. Eleanor discovers that Sam is a sex addict, and the two have sex in the hospital chapel; Eleanor later tells Jackie that she slept with Sam to give him an outlet to channel his addiction without turning to drugs. Jackie and Coop treat a cancer patient who isn't responding well to chemotherapy, and Coop strongly reprimands Jackie for recommending marijuana for the pain. Jackie privately teaches the patient how to make an apple bong and shows up at his apartment to give him pot brownies. While treating a young boy suffering from an allergic reaction, Zoey illegally intubates the boy without a doctor to save his life; Eleanor covers for Zoey and commends her work. Later, Zoey reveals to Jackie that she thinks she is pregnant.

Jackie gets into an argument with Kevin after discovering that he took their daughters on an outing with Kaitlyn and Ginny. In an effort to resolve pill shortages, Gloria posts a security guard by the Pill-O-Matix, and she reluctantly approaches Coop about being the public face of All Saints. Jackie treats a patient who is arrested for carrying an unlicensed gun, and she also reports the negligent caregiver of an elderly patient with dementia to the police. Eleanor reveals to Jackie that she used to be in a relationship with Sarah Khori, an international TV news correspondent. Sam decides to cut things off with Eleanor, admitting that his girlfriend is back in town. Zoey contemplates her possible pregnancy while also declining the advances of Lenny, an EMT worker. Jackie calls Eddie to reconnect.

Jackie resumes her sexual relationship with Eddie, but asks him to stop spending time with Kevin; Eddie ignores Jackie's requests and invites Kevin to play ping pong. Coop's advertisements for All Saints are plastered across the city, much to the disgust of Jackie and Eleanor. Jackie vandalizes the car of a wealthy businessman who drunkenly impaled her patient with an arrow. Sarah Khori makes a surprise visit to All Saints and rekindles her relationship with Eleanor, while Zoey happily announces that she is not pregnant after getting her period. With Eddie and the Pill-O-Matix becoming less reliable sources, Jackie finds an alternative way to get pills when a pharmaceutical company rep visits All Saints. Jackie allows Fiona to have a fake cast on her arm for her birthday.

Mrs. Sussman, the hospital's biggest donor, is brought into the ER, but refuses to continue funding after she is insulted by Coop, dismaying Gloria. When Mrs. Sussman dies from a stroke, Gloria proposes that Mrs. Sussman's dying wish was to reallocate money from the children's wing to the ER. Sarah asks Zoey to secretly treat her for a brown recluse spider bite. Jackie notices Sarah's philandering behavior and brings up her concerns to Eleanor, who ultimately decides to end their relationship. Jackie re-evaluates her affair with Eddie and temporarily breaks things off with him. When Fiona busts her lip open on her cast at home, Jackie gets Eleanor to stitch up Fiona in the kitchen, despite Kevin's objections that they go to the hospital. Later, Kevin lambasts Jackie for working too much and being tuned out at home, implying that Jackie is responsible for Grace's anxiety.

Fiona's teacher suspects that she is being abused because of her cast and lip injury, leading Jackie and Eleanor to remove the fake cast in-class to prove her arm is not broken. Grace attends her first session with a psychiatrist. At All Saints, a determined man refuses to leave the emergency room until he says goodbye to his dying husband. Jackie comforts a patient with a gunshot wound by promising that she will be next to her when she wakes up from surgery; Jackie forgets to follow through on her promise, leading the patient to reprimand her post-surgery. Jackie comforts Eleanor over her break-up with Sarah, and suggests that it is possible for someone to love two people at once, likening her relationship with Eddie and Kevin. Coop reunites with his friend Georgia and decides to set her up on a date with Eddie; Jackie is dismayed when Eddie takes Georgia to Kevin's bar.

Jackie wants to transfer Fiona to Grace's private school; Kevin is open to the idea, but continues to refuse Eleanor's money. Upon receiving a $600 credit card bill for prescription purchases, Jackie tells Eleanor that Kevin has agreed to set up an education fund for Fiona, intending to use the money to pay off her debt. Jackie also sets up a personal P.O. box to keep her credit card a secret. Frustrated with the Pill-O-Matix, Gloria invites Eddie to come back as the hospital's pharmacist. After allowing Sam to clock out for an hour to receive his six-month chip, Jackie intentionally reports him to Gloria, who puts Sam on probation. While treating a patient, Zoey reprimands Coop, who responds by involuntarily touching her breast; Lenny, unaware of Coop's Tourette's, comes to Zoey's defense and punches Coop. Jackie and Kevin discover that Grace is pulling her hair out from stress.

Eddie returns to All Saints as the hospital's pharmacist. The staff treat Marco Prince, a former linebacker who is diagnosed with early on-set dementia; Gloria tries to help Marco's wife by suggesting they get divorced for financial reasons, as he could qualify for Medicaid without her income. Zoey considers hooking up with Lenny, but Jackie cautions her about fooling around with co-workers. Sam invites Coop to spend time with his friends after work, during which Coop bonds with Sam's girlfriend. Jackie reveals her back pain to Eleanor, who agrees to give Jackie a prescription for Oxycontin after viewing her MRI. Later, Eleanor visits the hospital's orthopaedic department and is shocked to discover that Jackie has falsified her MRI. While walking home from work, Jackie tends to a man having a seizure. Jackie discovers baggies of pills in the man's pockets and steals them while waiting for paramedics to arrive.

Jackie evades Eleanor's questions about her fake MRI and instead decides to call off early to go on a road trip upstate with Kevin and the girls. Jackie hides a stash of pills in a floss container to get her through the vacation, but she misplaces the container when it falls out of her pocket in the car. Unable to find her pill stash, Jackie unravels and begins to experience withdrawal for the remainder of the trip; she also continues to ignore Eleanor's calls. At All Saints, Coop bonds with a patient who has Tourette's, and also reveals to Eddie that he had sex with Sam's girlfriend. The drug dealer whom Jackie helped while he had a seizure arrives at the hospital looking for Jackie. While staying at a bed and breakfast upstate, Jackie convinces Kevin to cut their trip early. On the journey back, Fiona answers Eleanor's phone call to Jackie; Eleanor asks Fiona about her new school, causing Jackie to aggressively ask for the phone back. Realizing that Jackie took Eleanor's money, Kevin pulls over and storms out of the car.

Jackie decides to drive off without Kevin, who calls Eddie for a ride home. When Kevin arrives home, Jackie admits that she took the money and tearfully claims that she took it to help the family, pointing out their financial problems. The following morning, Kevin finds Jackie's P.O. key and becomes suspicious. At All Saints, Jackie reconciles with Eleanor, who decides to overlook Jackie's reliance on pills. Zoey begins a fling with Lenny and gifts him a pocket watch. Jackie is physically confronted by the drug dealer whom she ripped off, but Thor tackles the man, knocking him out unconscious. Sam's girlfriend breaks up with him, and Sam punches Coop after discovering that he slept with her. When Sam goes on a bender, Jackie and Thor take him to the basement and tap-dance to keep him awake. Kevin visits the post office and discovers Jackie's credit card bill for prescriptions; he meets with Eleanor to discuss his findings. At the end of the episode, Jackie returns home and discovers that Kevin and Eleanor have staged an intervention for her.

Jackie vehemently denies being an addict to Kevin and insists that her credit card expenses were for their daughters. The following day, Jackie returns to work, where Eleanor continues to give her the cold shoulder and refuses to reconcile their friendship. To prevent Eleanor from reporting her, Jackie meets with Gloria and plays down her drug addiction, stating that she has been using painkillers strictly for pain. Jackie treats a young man who dies from renal failure after being crushed by a ton of boxes. Animosity is still rife between Sam and Coop, the latter of whom refuses to work with Sam. Zoey publicly announces her fling with Lenny to her co-workers. Kevin meets with an administrator at Grace's school about enrolling Fiona, and insists that he become the primary contact for the girls. The hospital staff discover that Jackie is married when Kevin arrives to confront her, revealing that he will be paying for Fiona's tuition.

Fiona starts at her new school. Gloria happily announces that All Saints is vying for a visit from Michelle Obama and attempts to rally the staff into initiating a campaign against childhood obesity to attract an official visit. Jackie discovers that Eleanor is looking for work at another hospital and tries to dissuade her, telling Eleanor that she will follow her to any hospital just to be near her; the two seemingly reconcile. Coop tries to bury the hatchet with Sam by publicly apologizing in front of the entire staff. Zoey discovers that the maternity ward is taking gloves from the emergency room and, under Gloria's advice, decides to steal them back. Eddie tells Jackie that he wants Kevin to know that he works at All Saints, as he now considers Kevin a real friend. Under Jackie's instructions, Eddie tells Kevin that he has lost his job; Kevin then asks Jackie to refer Eddie for a job at All Saints, which she agrees to.

Kevin's younger sister Tunie crashes at the Peyton household after breaking up with her pilot boyfriend. Jackie tells Eddie that she thinks Kevin brought Tunie over to monitor her in the wake of his intervention. At the hospital, a Jewish Orthodox husband fights to have his critically injured wife move to Beth Israel for an operation, while two street vendors are brought into the ER after being injured in turf war. Gloria receives a visit from a priest who wants to take back the statues in the hospital chapel. Lenny prepares a romantic lunch for Zoey, only for her to crack her tooth when she bites into a sandwich with his house key hidden inside. Zoey confides about her relationship with Lenny to God, who has set up a makeshift piano bar in the ambulance bay. Jackie has another encounter with Bill, the drug dealer she ripped off; Bill reveals that he is a former drug and alcohol counsellor, and offers to supply Jackie with pills in exchange for cash.

Kevin invites Eddie to a backyard barbecue at the Peyton household to celebrate his new job. Zoey works her first double shift and becomes addicted to her pedometer, while Gloria initiates her childhood obesity fundraiser. After learning that Gloria wants to name Eleanor as chief of the ER, Coop informs Gloria that he is putting his name in the running; Gloria invites Coop to prove himself worthy, despite having already offered Eleanor the position. Jackie treats a man named Lou, an out-of-work salesman who passed out before a job interview; Jackie discovers that Lou has high blood pressure and gives him a new prescription for meds. At home, Jackie finds an empty dresser and closet and believes that Kevin has left her; Tunie reveals that Kevin is currently attending an AA meeting, and has dropped off old clothes for a clothing drive held at the girls' school. Jackie arrives at the clothing drive to recover a pair of old mittens that have bags of pills stashed inside.

A rat eats Jackie's secret stash in the hospital basement, and Jackie panics when she realizes that her stash of pills is running low. Jackie confronts Eddie for his recent text exchanges with Tunie, but he maintains that it is completely innocent. Eleanor and Jackie deal with a mother making false claims about her daughter's health in order to stay on public assistance. Lou returns to All Saints, having lost his medical insurance after being laid off; Eleanor gives Lou a bag full of a year's worth of pills, and Jackie schedules him a psych evaluation for his depression. Coop remains determined to battle Eleanor for the ER chief title, but he becomes depressed upon learning that his two mothers are getting a divorce. Gloria asks Jackie and Thor to help move the Virgin Mary statue into the pharmacy backroom, where it will be safe from repossession during the chapel's de-consecration. Jackie meets with Bill and makes her first illicit drug transaction.

As her pill supply continues to dwindle, Jackie deceives Kevin into believing she is seeking treatment by searching for information about sobriety resources on the family laptop. At All Saints, Jackie clashes with Kelly Slater, the new temp nurse who bonds with the rest of the hospital staff and recounts his experience treating patients in Haiti. Gloria commiserates as the statues of the saints are finally removed from the chapel. Eleanor bonds with Tottie, a 95-year-old patient experiencing heart palpitations, while a patient consoles Coop, who is depressed about the split of his parents. Zoey treats a patient who expresses interest in asking out Lenny; Zoey gives Lenny the woman's number, but Lenny insists that he wants to remain with Zoey. Eddie considers going out with Tunie, but Jackie pleads with him to not move forward with the date. Depressed, Jackie is unable to walk through her own front door at the end of the day.

While dropping the girls off to school, Kevin discovers the dental floss dispenser that contains Jackie’s secret stash of pills underneath the passenger seat. Upon being confronted, Jackie protests that the pills are old, and reassures Kevin by showing him a 30-day sober chip that Bill has given her. At All Saints, a Native American patient momentarily lifts Coop's depression about his parents' divorce, while Zoey connects with Walker, a twelve-year-old boy whose mother was brought in for a drug overdose. Jackie tries to comfort Walker, but he lambasts his mother for being a drug addict. Kelly continues to win over the All Saints crew by inviting all of the hospital staff out for drinks. Eddie asks Kelly to deliver a bag of fentanyl patches for the oncology department. Jackie runs into Kelly and offers to deliver the drugs to oncology herself, but she ends up stealing some of the patches instead.

Jackie meets with Bill, but he reveals that he is out of pills and suggests that she visit his apartment at the end of the day. Jackie accuses Kelly of impropriety with two drunk high school girls, who have arrived at the ER after one of them faceplants on the sidewalk. Coop is attempting to throw away his childhood toys, which he has collected in his office during his depression. Thor helps Gloria navigate her new cell phone system. While treating a patient high on PCP, Eleanor is attacked while trying to remove the patient's restraints; Eddie offers to give Eleanor painkillers for the pain, but she refuses. Later, Jackie tries to get pills from Eddie, claiming it is for Eleanor, but he remains noncommittal. Jackie arrives at Bill's apartment, but he is accidentally struck and killed by an oncoming truck. Jackie flees the scene and arrives at Grace's school in time to watch her perform in the school pageant.

Following Bill's death, Jackie has run out of pills and begins to experience withdrawal; she tries to make it through the day by chugging a bottle of cough syrup and acquiring No-doz from Sam. Lenny is admitted into the ER after accidentally sticking himself with an epinephrine pen; Zoey uses Lenny's heart monitor as a lie detector to assess the seriousness of their relationship. Jackie and Eleanor treat a racist and misogynistic patient who has dislocated his shoulder; Jackie punishes the patient by sticking him with Lenny’s epi-pen. Eddie confronts Kelly about the missing fentanyl patches; Kelly meets with HR to resolve the issue, but claims that he does not know who he gave the bag of patches to. Coop decides to start his own family and tracks down an old girlfriend on Facebook. Jackie admits to Eleanor that she has been clean for 37 hours, and laments that she is unsure if she can make another hour.

Jackie and Kevin attend a meeting with Grace and her psychologist, during which Grace reveals that she wants to take medication to treat her anxiety. Upon discovering that HR believes an employee in the ER is abusing narcotics, Gloria puts Jackie on probation and forbids her from administering medication for patients in order to avoid an official investigation. Jackie lambasts Eleanor, believing that she was the one who reported her to HR, but Eleanor insists that she kept quiet about Jackie's pill addiction. Meanwhile, Zoey and Thor spend the day administering flu shots to the hospital staff, while Coop announces that he is getting married and offers to pay Gloria to book the chapel. Gloria accepts Coop's money and tries to offer it as a donation in exchange for the return of the saint statues in the chapel.

While practicing at the batting cage, an oddly evasive Kevin admits to Eddie that he has been unable to look at Jackie lately; Eddie informs Jackie that he believes Kevin is aware of their past affair. Coop asks Eddie to be his best man, but Eddie refuses, pointing out that Coop has only known his girlfriend for three weeks. Zoey throws a party for Nurses Appreciation Week that is sparsely attended, while Gloria receives bad news about the hospital's impending visit by the First Lady. Jackie begins abusing Grace's anxiety medication and reluctantly asks Eleanor to refill the prescription. Devastated, Eleanor tells Jackie that she is willing to pay for rehab and help Jackie get clean. Kelly discovers that Jackie is on probation and admits that he went to HR. He invites Jackie to go out for drinks after their shift, during which Jackie admits that she stole some of the fentanyl patches. In response, Kelly also makes a confession: he's never been to Haiti, and he also stole six of the fentanyl patches, causing Jackie to burst out laughing.

Gloria informs Jackie that HR has issued mandatory urine tests for nurses in the ER department. Fiona gets in trouble at school for playing with matches; Kevin tries to inform Jackie, but she continues to ignore his calls, trying to avoid an inevitable confrontation. Jackie, Eleanor and Kelly treat a patient with deafblindness who requests that they call his brother; Jackie tries to call the brother, only to discover that he is also admitted at the ER for injuries caused by a boiler explosion. The hospital staff gather for Coop's wedding ceremony in the chapel, but Coop is stood up at the altar. Jackie tries to console Coop by pointing out that he was able to restore the statues in the chapel. Jackie panics when Kevin arrives at All Saints to personally confront her. Suspecting that Kevin is planning to confront her about her relationship with Eddie, Jackie is surprised when Kevin admits that he had a brief affair. Although Kevin is willing to work things out, she instead demands that he move out. Gloria, reluctant to lose an excellent nurse, ultimately throws Jackie's urine sample in the trash, knowing that the results would test positive for banned substances.

Months after the season three finale, Jackie has broken up with Kevin. Eddie tries to resume his relationship with Jackie, but is hurt to realize that she only slept with him to get drugs. Eddie visits Kevin at his new house and reveals his past affair with Jackie, causing Kevin to beat him. All Saints has been bought out by a corporation called Quantum Bay; Mike Cruz, a physician with Quantum Bay, arrives to address the staff and establish his new role as chief administrator. In addition, Mike demotes Gloria and forces her to work on the floor as a nurse for two years to keep her pension. Jackie invites a druggie into her home to smoke heroin together. When the druggie overdoses and dies, Jackie calls Eleanor and Lenny to dispose of the body. Realizing that she has hit rock bottom, Jackie tearfully admits that she needs to go to rehab. The following day, Eleanor drives Jackie to rehab and reveals that she is pregnant.

Jackie begins treatment but is reluctant to open up to the group about the beginning of her addiction; she also struggles to connect with her strict counsellor Laura. At All Saints, Mike wants to make the hospital over into a trauma center with a helipad, while Eleanor finds herself at odds with Mike's administration. Meanwhile, Gloria tries to readjust to being back on the floor as a nurse while the other nurses feel torn about Quantum Bay's corporate swag. Jackie connects with Charlie, a teenage addict attending the same rehab center; Jackie admits to Charlie that her pill addiction began after giving birth to Grace. Jackie breaks down and calls Eleanor to sneak Grace into the rehab center. Jackie, pretending to work as a nurse at the center, briefly reunites with Grace, but she is caught by administration. Laura lambasts Jackie and threatens to kick her out of rehab, but ultimately allows her to stay, sternly reminding Jackie that she has to accept help in order to succeed in her recovery.

Jackie rushes to complete her twelve steps and leaves rehab after two weeks despite Laura's objections. Worried about Grace's recent rebellious behavior, Jackie visits Grace at school and unsuccessfully attempts to console her. Jackie returns to work but finds that sobriety has made her soft, breaking down to Eleanor when Coop makes a remark about her hair. Zoey begins to have second thoughts about her relationship with Lenny. Kelly gives Jackie a box of fentanyl patches, after which Jackie reports Kelly to Mike. Jackie then informs Kelly that somebody reported him for stealing drugs, forcing Kelly to flee. Eddie informs Jackie that he has told Kevin about their affair; Jackie calls Kevin, who reveals that he is keeping the girls for an extra night. When Jackie gets home, she finds a list of things Grace wants written on Grace's bedroom wall; Jackie spray paints "NOT GONNA HAPPEN" over the list.

While attending a local carnival, Grace tells Fiona and Zoey that Jackie went to rehab. Realizing that Grace has been aware of her addiction, Jackie rushes to inform Kevin about her stint in rehab before he hears about it from their daughter. Jackie goes to an AA meeting with Charlie, only to find out that he is using again. Charlie reveals that he is staying on his father's boat. Jackie and Eleanor treat Jules, a visibly pregnant woman who was involved in an altercation at a supermarket; Eleanor discovers that Jules is not pregnant but has a rare, terminal desmoid tumor. Jules bonds with Jackie and gives her a bottle of Vicodin; Jackie almost relapses, but ultimately throws the pills in a dumpster. Kevin has Eddie list what Jackie took from the pharmacy before telling Eddie to let Jackie know that she "just lost her kids." Meanwhile, Charlie reunites with his father, who is revealed to be Mike.

Missing her family and adjusting poorly to single life, Jackie tries to reconcile with Kevin and invites him to meet for lunch, only to be served with divorce papers instead. Mike creates a dress code for the nurses and asks Coop to reveal the new scrubs to the nurses, who react poorly to the announcement. Jackie treats a patient who lost his arm in a botched suicide attempt. After Mike refuses to let her treat a pregnant patient, Eleanor confronts Mike for dismissing her because of her pregnancy; Mike insists that he did so because of his experience in practicing obstetrics. Coop expresses an interest in raising his own family and buys Eleanor a present for her baby boy, which she rejects. Zoey rejects Lenny's offer to move in with him and sets up posters around the hospital looking for a roommate to split a new apartment, which Mike eventually orders her to take down. Zoey gratefully accepts Jackie's invitation to move in with her.

Jackie has a strange dream about relapsing at work. Jackie receives a call from Kevin's divorce lawyer, who reveals that Kevin is suing for custody of the girls. Mike assesses each departments' performance reviews and confronts Jackie, intrigued by her empty professional file. Jackie questions Gloria about her empty file, but receives no response. Jackie and Eleanor treat Lonna, an uninsured trans woman admitted to the ER for abdominal issues caused by estrogen; Gloria refers Lonna to a gender transition clinic that will pay for her medications. Zoey excitedly announces to the staff that she has gotten engaged to Lenny, but ends up losing her ring during her shift. Coop expresses an interest in becoming a father-figure to Eleanor's baby, but she dismisses him. Jackie receives a second call from Kevin's divorce lawyer and is distraught to discover that Kevin is trying to take her house. Jackie laments to Eleanor that "nothing started going bad" until she got sober.

Hoping to increase her chances of winning the custody battle, Jackie meets with a divorce lawyer but is reluctant to label Kevin as an unfit father. Gloria reunites with her old mentor, Dick Bobbitt, who has been admitted to the hospital and suffers from dementia. As Dick believes that he is still a practicing nurse, Jackie and Gloria temporarily allow him to help out on the floor until his daughter arrives. Sam, Thor and Coop accidentally drop a patient while transferring him from a gurney; Mike forbids the staff from admitting blame for the incident, but Dick ends up issuing a formal apology to the patient. Zoey begins to reconsider her engagement and decides to break up with Lenny, while Coop earnestly offers to help Eleanor raise her baby. Jackie attends another AA meeting with Charlie, but she dumps him as a confidant after she accidentally takes a sip of his Vicodin-spiked smoothie. When Charlie is arrested, Jackie decides to bail him out and urges him to contact his father. Jackie assists Charlie home and runs into Mike; Jackie is stunned to discover that he is Charlie's father.

While Jackie and Mike try to save Charlie from overdosing, Charlie angrily reveals Jackie's affair with Eddie to Mike. Afterwards, Charlie agrees to return to rehab if Mike promises that he will not fire Jackie. Meanwhile, Eddie is deposed by Kevin's divorce lawyer and discloses his affair with Jackie. Afterwards, Eddie decides to help Jackie with her divorce case by revealing that the girls were in the room when Kevin attacked him. Jackie discloses this revelation to her divorce lawyer, after which Kevin angrily confronts Jackie. Eleanor begins to consider accepting Coop's help and invites him to accompany her at her anatomy scan appointment. Lenny tells Zoey that he is moving to Greece to live with his cousins. Now aware of Jackie's stint in rehab, Mike blames Eddie for the narcotics shrinkage and fires him for enabling Jackie's addiction. Mike also reviews the hospital's old security camera footage and discovers proof of Gloria throwing away Jackie's urine sample; Mike confronts Jackie with the security footage and ruthlessly forces her to watch him fire Gloria.

Jackie refuses to allow Grace to transfer to public school. At All Saints, Mike lambasts the nurses for raising funds for Gloria and Eddie, while Jackie clashes with Mike over the firing of her colleagues. Eleanor discovers her patient has a subarachnoid hemorrhage and insists on scheduling an operation, but the patient is insistent on picking up her father, who has recently been admitted at Bellevue for a fall. Against Mike's objections, Zoey arrives at Bellevue and helps transfer the father to All Saints on a gurney to reunite with his daughter. Coop learns that Eleanor's sperm donor went to the same childhood camp as him, panicking Eleanor, who does not wish to know the identity of her donor. When an overflow of patients arrive at All Saints after being diverted from another hospital, Mike refuses to hire extra temp nurses and experiences a panic attack. After admitting Mike to pulmonary, Jackie seizes control of the ER to run it her way.

Operations run smoothly at the ER under Jackie's control. Upon waking up in his hospital room, Mike heads back to the ER and lambasts Jackie for overstepping her boundaries. In response, Jackie criticizes Mike's increasingly rigid management style and curses him out; Mike fires her, which riles the hospital staff to protest. While being escorted out by Mike and a security guard, Jackie makes a sarcastic retort about Mike keeping his son's promise. In the wake of her firing, Jackie immediately visits Grace to pull her out of class and allows her to transfer to public school. Meanwhile, Coop discovers the identity of Eleanor's sperm donor, but promises not to tell her. Eleanor goes into labor and tearfully calls Jackie to assist her. Jackie comes back to the hospital to visit Eleanor in maternity but is stopped by Mike; as the two begin to argue, Jackie is shocked to see that Charlie has just been admitted into the ER for a drug overdose. Mike unsuccessfully attempts to resuscitate Charlie, who dies moments after Eleanor has given birth to her baby boy.

Four months later, Jackie has returned to work after her union sued All Saints, Gloria has returned to her old job as hospital administrator, and two new doctors have joined the staff: Dr. Carrie Roman, an incompetent first-year resident skating by on looks, and Dr. Ike Prentiss, a former military doctor. Jackie treats a famous NFL player who has swallowed three condoms filled with drugs and blackmails him into buying a new CT machine for the hospital. The hospital staff struggle with the new pill dispenser, leading Eddie to bust the machine open and distribute the pills himself; Gloria is impressed and invites Eddie to return as the hospital pharmacist. Jackie struggles to maintain her sobriety and is upset when Eleanor reveals she is moving to London to prioritize raising her son. The day before her birthday, Jackie asks Kevin to let her have the girls for the celebration; Kevin chooses to keep the girls for the day, reprimanding Jackie to stick to the rules of their visitation agreement. Jackie decides to hide one pill in a small nightstand jewelry box.

On her birthday, Jackie and Kevin remain at odds over custody of the girls; Kevin insists on primary custody unless Jackie can resolve her long work hours. Coop is thrown off when Gloria announces Prentiss as the new ER chief. Carrie dismisses a returning patient with back pain as a pill addict, but Jackie and Prentiss discover that the patient actually has sepsis incurred from her previous hospital visit. Jackie receives a gift of birthday flowers from her father but refuses to accept them; Jackie later calls Charlie's phone and leaves a voicemail confiding about her day. Gloria begins to experience memory lapses, and Jackie takes advantage of Gloria's memory loss by tricking her into signing off on a shorter work schedule. Still hoping for primary custody, Kevin pushes for psychological testing on the girls. Jackie deters Kevin by asking Fiona to draw a picture of their family, a notable psychological assessment, and pointing out that Fiona has drawn Kevin separately from Jackie and the girls.

Jackie and Kevin finalize their divorce. While leaving the courtroom, Jackie accidentally rear-ends Kevin's car and is knocked unconscious by the airbags. She is admitted as a patient at All Saints, where Kevin berates Jackie and accuses her of being on drugs in front of her colleagues. Frank Verelli, a police officer investigating the accident, takes a liking to Jackie and flirts with her. Carrie treats Jackie and writes her a prescription for Oxycontin, unaware that she is an addict. Meanwhile, Zoey gets an apartment of her own, while Gloria continues to experience memory lapses throughout the day. Coop begins covering for Carrie and taking on a lot more work. Later, Coop confronts Carrie for her unprofessional behavior and involuntarily grabs her breast; in response, she gropes him. Jackie accepts Frank's offer to go out for coffee. The two have a good time, and Frank is accepting when Jackie admits to being a recovering drug addict.

Prentiss threatens to report Gloria to the hospital board for her recent memory lapses. When a heavily medicated woman who has been admitted to the ER goes missing, Jackie worries that Gloria has lost the patient. Gloria ultimately reveals that she has been helping the woman hide from her abusive husband, who has been drugging her against her will. Upon discovering Zoey and Thor sneaking the patient out of the hospital, Prentiss kindly reminds Jackie about standard hospital procedures. Coop invites Carrie to dinner, but she cancels their plans last minute to go on a date with the head of cardiology. Coop accuses Carrie of toying with his emotions, but the two end up having sex. Jackie faces conflicts with both of her daughters: Grace has been sneaking around the city with her older boyfriend Danny, and Fiona has been acting out at school. Realizing the extent of their daughters' problems, Jackie and Kevin agree to put up a unified front for the sake of the girls.

Jackie grows nervous as she prepares for her official date with Frank, and she ends up calling Charlie's phone to confide her frustrations. Elsewhere, Carrie and Coop continue their sexual relationship, Zoey helps deliver a baby, and Gloria proves her worth to Prentiss by identifying a spinal fracture in a patient that Prentiss had initially cleared for discharge. Zoey and Thor help Jackie choose an outfit for her date with Frank, which initially goes well until Jackie receives an unexpected call from Charlie's phone; Jackie answers the call and discovers it is Mike, who has followed her inside the restaurant and wishes to meet with her. Jackie leaves her date early and follows Mike to his apartment; she comforts him as he emotionally recounts Charlie's death, and the two end up having sex. While Jackie is away with Mike, Grace sneaks out to meet with Danny at a club but quickly becomes overwhelmed. She leaves the club alone and calls Jackie to pick her up.

Mike unexpectedly arrives at All Saints for his exit interview, stunning the staff. Jackie tells Mike that their sexual encounter was a one-time fling, but Mike tries to insist otherwise. In the chapel, Jackie and Mike have a frank conversation about Charlie, and Jackie reassures that Mike "did his best" in dealing with Charlie's addiction. Meanwhile, Prentiss dismisses a young patient whom he believes is looking to score drugs, but comes to learn that the patient is actually experiencing PTSD from his sister's death. Zoey is admitted as a patient after a showerhead falls on her forehead. Carrie tries to use flashcards to strengthen her skills but continues to manipulate Coop into doing more of her work anyways. After successfully setting a patient's nose back in place by hand, Carrie is motivated into having aggressive sex with Coop, which is accidentally recorded on Coop's voice recorder. After her shift, Jackie and Kevin punish Grace for lying and sneaking out. Jackie visits Mike at his apartment to wish him goodbye, and then heads off to go on a second date with Frank.

While transcribing dictation, Zoey accidentally hears the audio recording of Coop and Carrie having sex and informs Jackie. When Carrie fails to diagnose a patient's appendicitis, Jackie confronts Coop with the recording and instructs him to address Carrie's incompetence; Coop later stands up to Carrie and reprimands her to be a better doctor. Gloria forgets to hire a security escort for Jackie's psych patient, who winds up damaging the pharmacy. After failing to convince Gloria to see a doctor for her memory loss, Jackie and Eddie purposely throw out a few pills, which will require all of the hospital staff to take a mandatory blood test. In an effort to help the reserved Dr. Prentiss bond more with his colleagues, Zoey buys coffee for the entire hospital staff and pretends that it is from Prentiss. Jackie becomes worried when news that a cop has been shot reaches the hospital, and is relieved when she discovers that it is not Frank. Jackie reunites with Frank and reveals her genuine love and concern for him, realizing how important he is to her.

Jackie invites Frank to her house for dinner, but they are interrupted by Kevin; Jackie angrily lambasts Kevin for showing up unannounced, and Frank decides to leave. The next day, Frank urges Jackie to work out her unresolved issues with Kevin, which pushes Jackie to attend an AA meeting. While treating a patient who is unable to breathe, Carrie learns to trust herself and correctly diagnoses the patient's pneumothorax, impressing Prentiss. Upon reviewing Gloria's blood test, Jackie and Eddie consult with Gloria and deduce that her memory loss is being caused by a new medication that she had been taking for adult onset seizures. Zoey continues to bond with Prentiss by offering to organize his disaster of an office. Jackie discovers that Grace has skipped school and accuses her of sneaking out to meet with Danny, but Grace assures her that they have broken up. At the end of the episode, Jackie visits Kevin at the bar and apologizes for her past behavior, while Grace is revealed to be abusing drugs with Danny.

Jackie and Frank have sex for the first time, and Frank proclaims that he loves her, surprising Jackie. Kevin arrives at All Saints with Grace after discovering a bag of Adderall pills in Grace's backpack; Grace claims that the pills belong to Jackie, forcing both Jackie and Grace to get their blood drawn to prove who is telling the truth. In the process, Grace reveals that she found a pill hidden in Jackie's nightstand jewelry box. Zoey confronts Jackie, concerned that she did not get rid of the pill, but Jackie shuts her down. Meanwhile, Carrie begins shadowing Prentiss in order to further develop her skills; Coop misreads the situation and ultimately decides to break up with her. Gloria reprimands Zoey for taking over Prentiss's administrative duties, and Zoey and Prentiss are later revealed to have begun a sexual relationship. Returning home, Jackie tries to call Frank, but he rebuffs her for being distant. Jackie blames herself for Grace's experimentation with pills and informs Kevin that the girls should live with him for the time being.

As Jackie prepares to celebrate her one-year anniversary of sobriety, Jackie struggles to rekindle with Frank, who feels he has made an unreciprocated step forward in their relationship. Meanwhile, Thor connects with Wally, a gay 80-year-old patient dying of advanced liver cancer, and tearfully commends Wally for his legacy. Gloria fires Carrie after receiving an overwhelmingly negative performance review by her peers; however, upon consulting with a lawyer, Carrie reveals her sexual relationship with Coop and uses it as leverage to retain her position at All Saints. Zoey discovers that Grace is not attending Jackie's sobriety celebration and decides to pick her up at school; Grace is distraught and has an emotional breakdown about her mother. Frank reunites with Jackie and they reconcile, with Jackie admitting that she loves him. While getting ready for her anniversary party, Jackie nonchalantly takes the pill that she has been hiding in her jewelry box and swallows it. She then attends her anniversary party – which is attended by Kevin, Grace, Fiona, Frank, Eleanor, and the All Saints staff – and announces her one year of sobriety.

Jackie has relapsed and is back on pills that she's getting from a dealer at her gym; Grace is still doing lines of Adderall. At All Saints, Jackie's charged with shadowing Dr. Roman, fresh off her three-month probation. Dr. Prentiss talks to Akalitus about his relationship with Zoey. Jackie suddenly finds herself saddled with a sponsor.

Akalitus wins a nice car and Frank takes Jackie out on the town, where she finds a new dealer. Grace wants to go to France for an internship.

Grace is picked up for shoplifting, and spoils Kevin's secret. Zoey helps out the gay community and Dr. Prentiss cops some flack.

Jackie goes a little too far in her protection of Grace and Dr. Roman thanks Coop for his care of a patient. With Zoey's help, Dr Prentiss breaks some bad news to a friend. Jackie also finds out why Frank's marriage ended. Akalitus gets everyone lottery tickets.

Jackie finds out that Kevin and Mia are engaged and spies on Mia and finds her shopping with Grace. Frank tells Jackie he saw her do drugs the night before during poker night. Jackie moves her stashes into the women’s bathroom at the ER, but it gets moved. Later, Grace tells Frank Jackie is good at lying which encourages Frank to search the house and finds some of Jackie's stash. Jackie, Dr. Cooper, and apprehensive Dr. Roman take care of a nun in the ER. At dinner, Frank goes to discuss his findings with Jackie, but when Kevin and Mia invite them in, Mia reveals she is pregnant.

Jackie's fake identity is compromised. Frank tells Jackie’s sponsor what he found and she confronts Jackie. Jackie fires her as her sponsor. Jackie uses the credit card of her drug dealers girlfriend to buy dresses for her daughters. Dr. Prentiss tells Zoey he’s reenlisting. Grace starts experimenting with harder drugs.

Coop finally gets made Chief of the ER after Prentiss leaves. Zoey buries herself in work when Prentiss leaves and makes a friend of Dr. Roman. Grace gets an award at school. After, Jackie finds Oxy in Grace’s room. Frank and Jackie get in an argument and he leaves.

Jackie detoxes at home with help from Antoinette, Eddie, and Frank. Grace returns to the house with her friend to get the purse of drugs. Eddie tells her Jackie and Frank are in Miami and gives her the purse without any drugs. Jackie has vivid dreams of working.

Zoey throws a memorial for a member of staff who passes away, Coop and Carrie have sex on the hospital roof and Eddie takes Antoinette out for coffee. Jackie dodges a drug screening at work, yet again.

Jackie and Frank break up, Carrie forgets Coop's 40th Birthday, Zoey decides she wants to become a Nurse Practitioner, and the DEA investigation continues. Jackie realizes that the only way she can keep using is to separate herself from those closest to her.

Jackie brings her drug dealer as a guest to Kevin and Mia's wedding causing an embarrassing scene when Grace confronts her. Dr. Roman wants to meet Coop’s moms. Jackie gets the nun to agree to take the blame for Dr. Romans stolen DEA number. Zoey suspects Jackie put the blame on the nun and goes to Akalitus.

Zoey reveals to Akalitus that she believes Jackie is using again, prompting a demand by Akalitus for a drug test. Seeing no other alternative Jackie attempts to flee New York but a car crash on her way to the airport prevents her from making her get away. Shortly after attending to the injured car crash victim Jackie inadvertently crashes into a stationary ambulance resulting in her arrest. Dr. Roman informs Coop she is pregnant, and that he's the father.

Jackie is released from jail, but can't seem to get anyone to trust her anymore. Eddie tries to help out. The hospital adapts to life without Jackie. Coop and Dr. Roman try to keep their good news a secret. Jackie gets herself fired on purpose so she can go to a lawyer.

In order to pay for her lawyer, Jackie begins pawning off valued possessions, and resorts to dealing drugs; Zoey wants Jackie back in the hospital, unlike Akalitus.

Jackie is back to work at All Saints and Akalitus makes her job miserable so she’ll quit.Zoey is made Jackie's monitor; Dr. Roman has a miscarriage

Jackie continues to struggle under the diversion program without much may and owes her lawyer. Jackie can't get anyone to trust her when she reveals big news about the hospital being bought out by a European condo company. Coop thinks about proposing to Carrie.

It's Dr. Cooper's last day at the hospital before going to Boston and Carrie is not ready to say goodbye;Jackie organizes meetings to inform the staff about the Norwegians building condos. One of the Norwegians tries to make a deal with Jackie to be quiet in return helping her get her nursing license back; All Saints says hello to the new E.R. chief, Dr. Bernie Prince, who was working in the ICU prior. Zoey manages leading the new nurses. Jackie gives the USB drive of the condo plans to The NY Times.

After news of the condos being built went public, things get awkward at the hospital. Zoey and the rest of the nurses protest the selling of the hospital, leaving only doctors (and Jackie) to run the E.R. Jackie opens up to Dr. Prince about her past. Zoey, Thor, Akalitus, and other nurse temps get arrested for protesting. Jackie cancels plans with her daughters to work.

Jackie convinces Eddie decide to sell all their drugs at a "pill mill" so she has drugs completely out of her life so she can focus on getting her life back and impress her kids. Zoey and Carrie bond after the death of a patient and do shrooms in the park. Dr. Prince finds out the true reason why Akalitus shows no compassion towards Jackie; her son aided years ago.

All Saints enters escrow with the Norwegian developers; Jackie and Dr. Prince sneak around the hospital to get meds for a patient. Jackie learns something about Dr. Prince; Zoey and Carrie help Thor celebrate his wedding day.

Jackie and Zoey go on a road trip to save Grace, who is stranded in Pennsylvania; Dr. Prince sets out to help as many patients as possible before the hospital closes.

After inadvertently using, Jackie finds herself avoiding a drug test as she learns her nursing licence reinstatement hearing has been moved up to today; Dr. Prince begins to show symptoms of his condition; Eddie is questioned by his drug company about his conduct.

Following her contentious nursing license hearing, Jackie celebrates her return to her blue scrubs and continues her drug use. Akalitus takes off from work. Dr. Roman attempts to get even with Karlsen.

The hospital prepares to shut down. Jackie receives word that she secured a job at Bellevue and she wants Zoey to come with her. O'Hara returns and suspects that Jackie is using again. Elsewhere, Eddie is caught on tape drug dealing from Dr. Wu's pill mill. Eddie reveals to Jackie that their wedding has to be postponed because Eddie has to do one year in prison. Zoey turns down Jackie's offer. For its final night, the hospital throws a goodbye party. Jackie goes to the bathroom and snorts three lines of street-grade heroin that she found in a patient's bag. Jackie overdoses on the drugs on the hospital floor as her fate is left ambiguous.