| # | Mayor | Picture | Term | Party | Notes |
| 1st |
Charles Storer Storrow |
 |
1853–1854 |
Whig |
First mayor under the original city charter. |
| 2nd |
Enoch Bartlett |
|
1854–1855 |
Democratic |
|
| 3rd |
Albert Warren |
|
1855–1857 |
Native American Party |
|
| 4th |
John R. Rollins |
|
1857–1859 |
Whig |
|
| 5th |
Henry K. Oliver |
 |
1859–1860 |
Republican |
|
| 6th |
Daniel Saunders, Jr. |
|
1860–1861 |
Democratic |
Saunders was the founder of Lawrence. |
| 7th |
James K. Barker |
|
1861–1862 |
Republican |
|
| 8th |
William H. P. Wright |
|
1862–1864 |
Republican |
|
| 9th |
Alfred J. French |
|
1864–1865 |
Republican |
|
| 10th |
Milton Bonney |
|
1865–January 1, 1866 |
Republican |
|
| 11th |
Pardon Armington |
|
January 1, 1866–1867 |
Republican |
|
| 12th |
Nathaniel P. H. Melvin |
|
1867–1869 |
Democratic |
|
| 13th |
Frank Davis |
|
1869–January 3, 1870 |
Republican |
|
| 14th |
Nathaniel P. H. Melvin |
|
January 3, 1870–1871 |
Democratic |
|
| 15th |
S. B. W. Davis |
|
1871–1872 |
Republican |
|
| 16th |
John K. Tarbox |
 |
1873–January 4, 1875 |
Democratic |
|
| 17th |
Robert H. Tewksbury |
|
January 4, 1875–January 3, 1876 |
Republican |
|
| 18th |
Edmund R. Hayden |
|
January 3, 1876–1876 |
Democratic |
|
| 19th |
Caleb Saunders |
|
January 1, 1877–1877 |
Democratic |
|
| 20th |
James R. Simpson |
|
1878–1880 |
Republican |
|
| 21st |
Henry Kingman Webster |
|
1881–1881 |
Republican |
|
| 22nd |
John Breen |
 |
1882–1884 |
Democratic |
First Irish born or Roman Catholic Mayor in New England. |
| 23rd |
James R. Simpson |
|
1885–1885 |
Republican |
|
| 24th |
Alexander B. Bruce |
 |
1886–1887 |
Democratic |
|
| 25th |
Alvin E. Mack |
|
1888–1889 |
Republican |
|
| 26th |
John W. Crawford |
|
1890–1890 |
Democratic |
|
| 27th |
Lewis P. Collins |
|
1891–1891 |
Republican |
|
| 28th |
Henry P. Doe |
|
1892–1892 |
Democratic |
|
| 29th |
Alvin E. Mack |
|
1893–1893 |
Republican |
|
| 30th |
Charles G. Rutter |
|
1894–1895 |
Democratic |
|
| 31st |
George S. Junkins |
|
1896–1897 |
Republican |
|
| 32nd |
James H. Eaton |
|
1898–1899 |
Republican |
|
| 33rd |
James F. Leonard |
|
1900–1902 |
Democratic |
|
| 34th |
Alexander F. Grany |
|
1903–January 4, 1904 |
|
|
| 35th |
Cornelius F. Lynch |
|
January 4, 1904–1905 |
|
|
| 36th |
John P. Kane |
|
1906–1908 |
|
|
| 37th |
William P. White |
|
1909–July 25, 1910 |
|
Resigned after he was convicted on bribery charges and sentenced to three years in the house of correction. White's resignation was effective when accepted by both branches of the city council on July 25, 1910. |
| Acting |
Thomas M. Jordan |
|
July 25, 1910–August 29, 1910 |
|
Served as acting mayor in his role as chairman of the board of aldermen. |
| 38th |
John T. Cahill |
|
August 29, 1910–January 1, 1912 |
Democratic |
Elected by a joint session of the city council to fill the vacancy caused by White's resignation. |
| 39th |
Michael A. Scanlon |
|
January 1, 1912–August 16, 1914 |
|
A new city charter went into effect on January 1, 1912, creating a commission form of government and giving the mayor a two-year term beginning with Scanlon. On January 15, 1912, Scanlon requested the state militia to suppress the 'Bread and Roses strike', resulting in the death of a striker. On February 24, 1912, Scanlon ordered police to prevent striking workers' children from traveling to Washington, D.C., for a protest march. The mothers and children were beaten as they gathered at the train station. Scanlon died in office. |
| 40th |
John P. Kane |
|
1914–1915 |
|
To fill vacancy |
| 41st |
John J. Hurley |
|
1916–1919 |
|
|
| 42nd |
William P. White |
|
1920–1921 |
|
|
| 43rd |
Daniel W. Mahoney |
|
1922–1923 |
|
| 44th |
Walter T. Rochefort |
|
1924–1928 |
|
|
| 45th |
Michael A. Landers |
|
1928–1931 |
|
| 46th |
William P. White |
|
1932–1933 |
|
|
| 47th |
Walter A. Griffin |
|
1934–1942 |
|
|
| 48th |
James P. Meehan |
|
1942–1951 |
Democratic |
|
| 49th |
John J. Buckley |
|
1952–1965 |
Democratic |
|
| 50th |
Daniel P. Kiley, Jr. |
|
1966–1971 |
|
|
| 51st |
John J. Buckley |
|
1972–1977 |
Democratic |
|
| 52nd |
Lawrence P. LeFebre |
|
1978–1983 |
Democratic |
|
| 53rd |
John J. Buckley |
|
1984-January 2, 1986 |
Democratic |
|
| 54th |
Kevin J. Sullivan |
|
January 2, 1986–1991 |
Democratic |
Switched from Democrat to Republican[1] |
| 1991–1993 |
Republican |
Resigned to accept an appointment as head of State Transportation |
| Acting |
George Miller |
|
1993 |
|
|
| Acting |
Leonard J. Degnan |
|
1993 |
Democratic |
|
| 55th |
Mary Claire Kennedy |
|
1993–1998 |
Republican |
|
| 56th |
Patricia Dowling |
|
1998–2001 |
Democratic |
Resigned to accept an appointment as a state district court judge. |
| Acting |
Marcos Devers |
 |
September 2001 – November, 2001 |
Democratic |
First Hispanic mayor of Lawrence. |
| 57th |
Michael J. Sullivan |
|
November 2001 - January 4, 2010 |
Republican |
|
| 58th |
William Lantigua |
 |
January 4, 2010 – January 4, 2014 |
Democratic |
|
| 59th |
Dan Rivera |
 |
January 4, 2014 - January 9, 2021 |
Democratic |
|
| Acting |
Kendrys Vasquez |
 |
January 9, 2021 – November 12, 2021 |
Democratic |
|
| 60th |
Brian De Peña |
 |
November 12, 2021 - |
Democratic |
|