MIS18BP1

MIS18BP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGX
Identifiers
Aliases	MIS18BP1, C14orf106, HSA242977, KNL2, M18BP1, MIS18 binding protein 1
External IDs	OMIM: 618139; MGI: 2145099; HomoloGene: 10147; GeneCards: MIS18BP1; OMA:MIS18BP1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	45,253,540 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	65,219,378 bp
RNA expression pattern
	Top expressed in
	monocyte; ; ventricular zone; ; testicle; ; epithelium of colon; ; tendon of biceps brachii; ; gonad; ; ganglionic eminence; ; buccal mucosa cell; ; Achilles tendon; ; rectum;
	Top expressed in
	genital tubercle; ; tail of embryo; ; abdominal wall; ; zygote; ; medial ganglionic eminence; ; primitive streak; ; maxillary prominence; ; renal corpuscle; ; oocyte; ; mandibular prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	chromosome; chromosome, centromeric region; nucleus; nucleoplasm;
Biological process	cell division; cell cycle; CENP-A containing chromatin assembly; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	55320
	217653
	ENSG00000129534
	ENSMUSG00000047534
	Q6P0N0
	Q80WQ8
	NM_018353
	NM_172578
	NP_060823
	NP_766166
	Wikidata
View/Edit Human	View/Edit Mouse

MIS18 binding protein 1 is a protein that in humans is encoded by the MIS18BP1 gene.^[5]^[6]^[7] The gene is also known as LKNL2, M18BP1, C14orf106, and HSA242977^[5]. M18BP1 protein is an important component in the CENPA deposition pathway, and in most eukaryotes M18BP1 is necessary for chromosome segregation.