ML148

ML148 is a drug which acts as a reasonably potent and selective inhibitor of the enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH), with an IC₅₀ of 56 nM. It increases levels of prostaglandin E2 and stimulates tissue regeneration. It was one of the earliest selective 15-PGDH inhibitors developed, and is now mainly significant as a lead compound which was used to develop more potent derivatives such as HW201877, but is still used in research as its simple chemical structure and straightforward synthesis makes it a cost-effective alternative to more complex compounds.^[1][2][3]

Drug class15-PGDH inhibitor

CAS Number

• 451496-96-1

PubChem CID

• 3243760

ChemSpider

• 2494586

Quick facts Clinical data, Drug class ...

ML148

Clinical data
Drug class	15-PGDH inhibitor
Identifiers
IUPAC name [1-(3-methylphenyl)benzimidazol-5-yl]-piperidin-1-ylmethanone
CAS Number	451496-96-1
PubChem CID	3243760
ChemSpider	2494586
ChEBI	CHEBI:92799
ChEMBL	ChEMBL1343061
Chemical and physical data
Formula	C20H21N3O
Molar mass	319.408 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC(=CC=C1)N2C=NC3=C2C=CC(=C3)C(=O)N4CCCCC4
InChI InChI=1S/C20H21N3O/c1-15-6-5-7-17(12-15)23-14-21-18-13-16(8-9-19(18)23)20(24)22-10-3-2-4-11-22/h5-9,12-14H,2-4,10-11H2,1H3 Key:YQNOQZALLOQMPY-UHFFFAOYSA-N

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