MMB-2201

MMB-2201 (also known as MMB-5F-PICA,^[1] 5F-MMB-PICA, 5F-AMB-PICA, and I-AMB) is a potent indole-3-carboxamide based synthetic cannabinoid,^[2] which has been sold as a designer drug and as an active ingredient in synthetic cannabis blends.^[3] It was first reported in Russia and Belarus in January 2014, but has since been sold in a number of other countries. In the United States, MMB-2201 was identified in Drug Enforcement Administration drug seizures for the first time in 2018.^[4]

Legal status

• CA: Schedule II
• DE: Anlage II (Authorized trade only, not prescriptible)
• UK: Class B

CAS Number

• 1616253-26-9

PubChem CID

• 119058037

ChemSpider

• 30922499

Quick facts Legal status, Identifiers ...

MMB-2201

Legal status
Legal status	CA: Schedule II DE: Anlage II (Authorized trade only, not prescriptible) UK: Class B
Identifiers
IUPAC name (S)-Methyl 2-(1-(5-fluoropentyl)-1H-indole-3-carboxamido)-3-methylbutanoate
CAS Number	1616253-26-9
PubChem CID	119058037
ChemSpider	30922499
UNII	744M0WHE80
CompTox Dashboard (EPA)	DTXSID501342492
Chemical and physical data
Formula	C20H27FN2O3
Molar mass	362.445 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)[C@@H](C(=O)OC)NC(=O)c1cn(c2c1cccc2)CCCCCF
InChI InChI=1S/C20H27FN2O3/c1-14(2)18(20(25)26-3)22-19(24)16-13-23(12-8-4-7-11-21)17-10-6-5-9-15(16)17/h5-6,9-10,13-14,18H,4,7-8,11-12H2,1-3H3,(H,22,24)/t18-/m0/s1 Key:JFXASAFVUQVGEW-SFHVURJKSA-N

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MMB-2201 is the indole core analogue of 5F-AMB. Synthetic cannabinoid compounds with an indole-3-carboxamide or indazole-3-carboxamide core bearing a N-1-methoxycarbonyl group with attached isopropyl or tert-butyl substituent, have proved to be much more dangerous than older synthetic cannabinoid compounds previously reported, and have been linked to many deaths in Russia, Japan, Europe and the United States.^[5][6]