MPP6

MAGUK p55 subfamily member 6 is a protein that in humans is encoded by the MPP6 gene.^[5][6][7]

AliasesPALS2, VAM1, membrane palmitoylated protein 6, protein associated with LIN7 2, MAGUK family member, protein associated with LIN7 2, MAGUK p55 family member, MPP6, VAM-1, p55T

External IDsOMIM: 606959; MGI: 1927340; HomoloGene: 22976; GeneCards: PALS2; OMA:PALS2 - orthologs

Chr.Chromosome 7 (human)^[1]

End24,694,193 bp^[1]

Quick facts PALS2, Identifiers ...

PALS2
Identifiers
Aliases	PALS2, VAM1, membrane palmitoylated protein 6, protein associated with LIN7 2, MAGUK family member, protein associated with LIN7 2, MAGUK p55 family member, MPP6, VAM-1, p55T
External IDs	OMIM: 606959; MGI: 1927340; HomoloGene: 22976; GeneCards: PALS2; OMA:PALS2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.3 Start 24,573,268 bp[1] End 24,694,193 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B2.3|6 24.13 cM Start 50,087,221 bp[2] End 50,175,919 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon islet of Langerhans testicle tibia left testis gallbladder right testis gonad sural nerve sperm Top expressed in interventricular septum medullary collecting duct right kidney seminiferous tubule endothelial cell of lymphatic vessel temporal muscle tail of embryo proximal tubule spermatid otic placode More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding protein binding Cellular component plasma membrane extracellular exosome membrane Biological process protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51678 56524 Ensembl ENSG00000105926 ENSMUSG00000038388 UniProt Q9NZW5 Q9JLB0 RefSeq (mRNA) NM_001303037 NM_016447 NM_001164733 NM_001164734 NM_008016 NM_019939 NM_001361247 NM_001361248 RefSeq (protein) NP_001289966 NP_057531 NP_001158205 NP_001158206 NP_064323 NP_001348176 NP_001348177 Location (UCSC) Chr 7: 24.57 – 24.69 Mb Chr 6: 50.09 – 50.18 Mb PubMed search [3] [4]
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Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001).[supplied by OMIM]^[7]