Milsaperidone

Medication From Wikipedia, the free encyclopedia

Milsaperidone, sold under the brand name Bysanti, is an atypical antipsychotic used for the treatment of schizophrenia and bipolar disorder.[1][2] It is a prodrug of iloperidone and acts as a dopamine D2 receptor and serotonin 5-HT2A receptor antagonist, among other actions.[3][4] Milsaperidone was developed by Vanda Pharmaceuticals.

Other namesVHX896, VHX-896
License data
Quick facts Clinical data, Trade names ...
Milsaperidone
Clinical data
Trade namesBysanti
Other namesVHX896, VHX-896
AHFS/Drugs.combysanti
License data
Routes of
administration
Oral
Drug classAtypical antipsychotic
ATC code
  • None
Legal status
Legal status
Identifiers
  • (1S)-1-[4-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-methoxyphenyl]ethanol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC24H29FN2O4
Molar mass428.504 g·mol−1
3D model (JSmol)
  • C[C@@H](C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC)O
  • InChI=1S/C24H29FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-17,28H,3,8-13H2,1-2H3/t16-/m0/s1
  • Key:SBKZGLWZGZQVHA-INIZCTEOSA-N
Close

Milsaperidone was approved for medical use in the United States in February 2026.[5]

Medical uses

Milsaperidone is indicated for the treatment of schizophrenia; and for the acute treatment of manic or mixed episodes associated with bipolar I disorder.[1]

Society and culture

Milsaperidone was approved for medical use in the United States in February 2026.[6]

Names

Milsaperidone is the international nonproprietary name.

Milsaperidone is sold under the brand name Bysanti.[6]

Research

Milsaperidone is in phase III clinical trials for treatment of major depressive disorder.[7][8]

References

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