Mir-650 microRNA precursor family

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In molecular biology mir-650 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-650 is one of a group of six miRNAs with altered expression levels in diabetic and non-diabetic heart failure. This altered expression corresponds to various enriched cardiac dysfunctions.[1]

NDRG2 regulation

miR-650 has further been reported to target a homologous DNA region in the promoter region of the NDRG2 gene.[2] There is direct regulation of this gene at a transcriptional level, leading to repressed NDRG2 expression.

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