Mir-744 microRNA precursor family
From Wikipedia, the free encyclopedia
miR-744 plays a role in tumour development and growth in mouse cell lines. Its expression induces cyclin B1 expression, whilst knockdown sees a resultant decreased level of mouse cyclin B through the Ccnb1 gene.[1] Short-term overexpression of miR-744 in mouse cell lines has been seen to enhance cell proliferation, whilst chromosomal instability and in vivo suppression are concurrent with a prolonged expression.
TGF-β1 repression
Multiple miR-744 binding sites have been identified in the proximal 3' untranslated region of transforming growth factor beta 1 (TGF-β1). Direct targeting of TGF-β1 by miR-744 has been identified, and transfection is seen to inhibit endogenous TGF-β1 synthesis by directing post-transcriptional regulation.[2]
EEF1A2 repression
miR-744 directly targets translation elongation factor and known protooncogene EEF1A2.[3] mIR-744 also upregulates during resveratrol treatment of MCF7 breast cancer cells.[4]
