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NRL (gene)

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Neural retina-specific leucine zipper protein is a protein that in humans is encoded by the NRL gene.[5][6][7]

AliasesNRL, D14S46E, NRL-MAF, RP27, neural retina leucine zipper
External IDsOMIM: 162080; MGI: 102567; GeneCards: NRL
End24,115,010 bp[1]
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NRL
Identifiers
AliasesNRL, D14S46E, NRL-MAF, RP27, neural retina leucine zipper
External IDsOMIM: 162080; MGI: 102567; GeneCards: NRL
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006177
NM_001354768
NM_001354769
NM_001354770

NM_001136074
NM_001271916
NM_001271917
NM_008736

RefSeq (protein)

NP_006168
NP_001341697
NP_001341698
NP_001341699

NP_001129546
NP_001258845
NP_001258846
NP_032762

Location (UCSC)Chr 14: 24.08 – 24.12 MbChr 14: 55.76 – 55.76 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoreceptor cell development and function. Mutations in this gene have been associated with retinitis pigmentosa and degenerative diseases of the retina.[7]

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