Nornuciferine

Nornuciferine
Clinical data
Other names	15781; 1,2-Dimethoxynoraporphine; N-Nornuciferine
Drug class	Serotonin 5-HT2C receptor agonist
ATC code	None;
Identifiers
	IUPAC name 1,2-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline;
CAS Number	54750-04-8;
PubChem CID	624491;
ChemSpider	542509;
UNII	XUR3H4VB7J;
CompTox Dashboard (EPA)	DTXSID40203210 ;
Chemical and physical data
Formula	C18H19NO2
Molar mass	281.355 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=C(C2=C3C(CC4=CC=CC=C42)NCCC3=C1)OC;
	InChI InChI=1S/C18H19NO2/c1-20-15-10-12-7-8-19-14-9-11-5-3-4-6-13(11)17(16(12)14)18(15)21-2/h3-6,10,14,19H,7-9H2,1-2H3; Key:QQKAHDMMPBQDAC-UHFFFAOYSA-N;

Nornuciferine, also known as 15781 or as 1,2-dimethoxynoraporphine, is a noraporphine alkaloid found in Nelumbo nucifera and a serotonin 5-HT_2C receptor agonist related to the aporphine alkaloid nuciferine.^[1]^[2] It is the N-desmethyl analogue of nuciferine.^[1]^[2] The drug has been found to act as a selective partial agonist of the serotonin 5-HT_2C receptor, with an EC₅₀Tooltip half-maximal effective concentration of 653 nM and an E_maxTooltip maximal efficacy of 66% in terms of G_q signaling.^[1] Conversely, it was inactive as an agonist of the serotonin 5-HT_2A and 5-HT_2B receptors, but did show weak antagonism of these receptors at high concentrations.^[1] The serotonin 5-HT_2C receptor agonism of nornuciferine was described by Bingjie Zhang and colleagues in 2020.^[1]