PAIP1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Polyadenylate-binding protein-interacting protein 1 is a protein that in humans is encoded by the PAIP1 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesPAIP1, poly(A) binding protein interacting protein 1
Quick facts Available structures, PDB ...
PAIP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPAIP1, poly(A) binding protein interacting protein 1
External IDsOMIM: 605184; MGI: 2384993; HomoloGene: 4709; GeneCards: PAIP1; OMA:PAIP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006451
NM_182789
NM_183323

NM_001079849
NM_145457

RefSeq (protein)

NP_006442
NP_877590
NP_899152

NP_001073318
NP_663432

Location (UCSC)Chr 5: 43.53 – 43.56 MbChr 13: 119.57 – 119.59 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[7]

Interactions

PAIP1 has been shown to interact with PABPC1.[5][8]

References

Further reading

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