PALM

Paralemmin is a protein that in humans is encoded by the PALM gene.^[5][6][7]

AliasesPALM, paralemmin, PALM1

External IDsOMIM: 608134; MGI: 1261814; HomoloGene: 1937; GeneCards: PALM; OMA:PALM - orthologs

Chr.Chromosome 19 (human)^[1]

End748,329 bp^[1]

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PALM
Identifiers
Aliases	PALM, paralemmin, PALM1
External IDs	OMIM: 608134; MGI: 1261814; HomoloGene: 1937; GeneCards: PALM; OMA:PALM - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 708,935 bp[1] End 748,329 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 79,629,406 bp[2] End 79,656,730 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amygdala right frontal lobe nucleus accumbens cingulate gyrus anterior cingulate cortex caudate nucleus putamen prefrontal cortex ganglionic eminence Brodmann area 9 Top expressed in entorhinal cortex perirhinal cortex dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex CA3 field granulocyte ventricular zone neural tube right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function D3 dopamine receptor binding protein binding Cellular component cytoplasm cell projection intracellular membrane-bounded organelle membrane filopodium plasma membrane dendritic spine integral component of plasma membrane dendrite membrane axon apicolateral plasma membrane dendrite basolateral plasma membrane dendritic spine membrane neuron spine nucleus filopodium membrane postsynaptic density cytoplasmic vesicle intrinsic component of the cytoplasmic side of the plasma membrane Biological process protein localization negative regulation of adenylate cyclase activity cytoskeleton organization synapse maturation regulation of cell shape negative regulation of dopamine receptor signaling pathway cellular response to electrical stimulus positive regulation of filopodium assembly protein localization to plasma membrane adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5064 18483 Ensembl ENSG00000099864 ENSMUSG00000035863 UniProt O75781 Q9Z0P4 RefSeq (mRNA) NM_001040134 NM_002579 NM_001161747 NM_023128 RefSeq (protein) NP_001035224 NP_002570 NP_001155219 NP_075617 Location (UCSC) Chr 19: 0.71 – 0.75 Mb Chr 10: 79.63 – 79.66 Mb PubMed search [3] [4]
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This gene encodes a member of the paralemmin protein family. Other members of this family include CAP-23, GAP-43, MARCKS, and MacMARCKS. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types.^[5][6] Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.^[7]