Zinc finger and BTB domain-containing protein 16
Protein found in humans
From Wikipedia, the free encyclopedia
Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.
Function
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL)[5] and physiological roles have been identified in mouse Natural Killer T cells[6][7] and gamma-delta T cells.[8] Alternate transcriptional splice variants have been characterized in human.[9][10]
Interactions
Zinc finger and BTB domain-containing protein 16 has been shown to interact with:
- Angiotensin II receptor type 1,[11]
- BCL6,[12]
- BMI1,[13]
- Calcitriol receptor,[14][15]
- FHL2,[16]
- GATA1,[17]
- GATA2,[18]
- HDAC1,[19][20][21]
- HDAC4,[19][22]
- HDAC5,[19][22]
- HDAC6,[19]
- Heparin-binding EGF-like growth factor,[23][24]
- Nuclear receptor co-repressor 2,[21][25][26]
- Promyelocytic leukemia protein[27]
- RUNX1T1,[28][29]
- Retinoic acid receptor alpha,[30]
- SIN3A,[14][20][21]
- SIN3B,[20] and
- ZBTB32.[31]