HDAC1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.[5]
Function
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.[6]
Interactions
HDAC1 has been shown to interact with:
- Androgen receptor,[7]
- BCL6,[8][9]
- BTG2,[10][11]
- BUB1B,[12]
- BUB1,[12]
- BUB3,[12]
- CBFA2T3,[13][14]
- CDC20,[12]
- CDH1,[12]
- CHD3,[15][16]
- CHD4,[15][17][18]
- COUP-TFII,[19]
- CTBP1,[20][21][22]
- DDX17,[23]
- DDX5,[23]
- DNMT3A,[24]
- DNMT3L,[25][26]
- Death-associated protein 6,[27]
- EED,[28]
- EVI1,[29][30]
- EZH2,[28]
- FKBP3,[31]
- GATA1,[32]
- HMG20B,[33]
- HSPA4,[34]
- HUS1,[35]
- Histone deacetylase 2,[15][17][28][33][34][36][37][38][39][40][41][42][43]
- Homeobox protein TGIF1,[20][44]
- Host cell factor C1,[45]
- IFRD1,[46]
- IKZF1,[47][48]
- ING1,[16][49]
- MBD3,[41][50][51]
- MIER1,[52]
- MLL,[53]
- MTA1,[17][54]
- MTA2,[17][41][55][56]
- Mad1,[12]
- Mdm2,[57]
- Methyl-CpG-binding domain protein 2,[41][58][59]
- Mothers against decapentaplegic homolog 2,[60]
- MyoD,[61][62]
- NFKB1,[63]
- Nuclear receptor co-repressor 2,[36][64]
- P21,[65]
- PCNA,[66]
- PHF21A,[33][67]
- Prohibitin,[68][69]
- Promyelocytic leukemia protein,[70][71]
- RAD9A,[35]
- RBBP4,[17][18][41][42][43][55][58][72][73][74][75]
- RBBP7,[17][41][43][58]
- RCOR1,[33][55]
- RELA,[40][63][76]
- RFC1,[77]
- Retinoblastoma protein,[61][69][78][79][80][81][82]
- Retinoblastoma-like protein 1,[78][79]
- Retinoblastoma-like protein 2,[78][83]
- SAP30,[16][41][84][85][86][87]
- SATB1,[56]
- SIN3A,[15][16][17][18][41][42][55][56][72][73][88][89][90][91]
- SIN3B,[41][47]
- SPEN,[92]
- SUDS3,[88][93]
- SUV39H1,[94]
- Sp1 transcription factor,[73][95][96][97]
- TOP2A,[98][99]
- TOP2B,[98][99] and
- Zinc finger and BTB domain-containing protein 16.[8][100][101]
