SIN3A
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.[5][6]
AliasesSIN3A, Paired amphipathic helix protein Sin3a, SIN3 transcription regulator family member A, WITKOS
External IDsOMIM: 607776; MGI: 107157; HomoloGene: 32124; GeneCards: SIN3A; OMA:SIN3A - orthologs
Function
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.[7]
Interactions
SIN3A has been shown to interact with:
- CABIN1[8]
- HBP1,[9]
- HDAC1,[10][11][12][13][14][15][16][17][18][19][20][21][22][23]
- HDAC9,[24][25]
- Histone deacetylase 2,[10][12][13][18][19][26][27]
- Host cell factor C1,[28][29]
- IKZF1,[24][30][31]
- ING1,[23]
- KLF11,[32][33]
- MNT,[34]
- MXD1,[9][35][36]
- Methyl-CpG-binding domain protein 2,[37]
- Nuclear receptor co-repressor 2,[22][38]
- OGT,[39]
- PHF12,[40]
- Promyelocytic leukemia protein,[41]
- RBBP4,[42][43]
- RBBP7,[23][43]
- SAP130,[12]
- SAP30,[12][17][23][40][43][44]
- SMARCA2,[45]
- SMARCA4,[23][45]
- SMARCC1,[23][45]
- SUDS3,[12][46]
- TAL1,[47] and
- Zinc finger and BTB domain-containing protein 16.[48][49][50]