PPP2R5D

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform is an enzyme that in humans is encoded by the PPP2R5D gene.[5][6] Mutations in PPP2R5D cause Jordan's syndrome.

AliasesPPP2R5D, B56D, MRD35, protein phosphatase 2 regulatory subunit B'delta, B56delta
End43,012,342 bp[1]
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PPP2R5D
Identifiers
AliasesPPP2R5D, B56D, MRD35, protein phosphatase 2 regulatory subunit B'delta, B56delta
External IDsOMIM: 601646; MGI: 2388481; HomoloGene: 37661; GeneCards: PPP2R5D; OMA:PPP2R5D - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_180977
NM_001270476
NM_006245
NM_180976

NM_009358
NM_001357684

RefSeq (protein)

NP_001257405
NP_006236
NP_851307
NP_851308

n/a

Location (UCSC)Chr 6: 42.98 – 43.01 MbChr 17: 46.99 – 47.02 Mb
PubMed search[3][4]
Wikidata
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Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]

Interactions

PPP2R5D has been shown to interact with:

References

Further reading

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