PRPF19

Pre-mRNA-processing factor 19 is a protein that in humans is encoded by the PRPF19 gene.^[5][6]

AliasesPRPF19, NMP200, PRP19, PSO4, SNEV, UBOX4, hPSO4, pre-mRNA processing factor 19

External IDsOMIM: 608330; MGI: 106247; GeneCards: PRPF19

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 11 (human)^[1]

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PRPF19
Identifiers
Aliases	PRPF19, NMP200, PRP19, PSO4, SNEV, UBOX4, hPSO4, pre-mRNA processing factor 19
External IDs	OMIM: 608330; MGI: 106247; GeneCards: PRPF19
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LG8
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.2.27 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.2 Start 60,890,547 bp[1] End 60,906,585 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 7.33 cM Start 10,872,595 bp[2] End 10,886,923 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons right frontal lobe Brodmann area 9 ventricular zone ganglionic eminence prefrontal cortex cerebellar hemisphere right hemisphere of cerebellum anterior pituitary islet of Langerhans Top expressed in aortic valve primitive streak motor neuron ascending aorta fossa right ventricle epiblast Paneth cell facial motor nucleus ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase activity ubiquitin-protein transferase activity ubiquitin-ubiquitin ligase activity protein binding identical protein binding transferase activity Cellular component site of double-strand break nuclear speck catalytic step 2 spliceosome membrane lipid droplet spindle Prp19 complex DNA replication factor A complex spliceosomal complex cytoskeleton nucleus cytoplasm nucleoplasm U2-type catalytic step 1 spliceosome U2-type catalytic step 2 spliceosome Biological process mRNA splicing, via spliceosome spliceosomal tri-snRNP complex assembly lipid biosynthetic process negative regulation of neuron differentiation positive regulation of astrocyte differentiation positive regulation of mRNA splicing, via spliceosome protein K63-linked ubiquitination mRNA processing protein polyubiquitination inner cell mass cell proliferation cellular response to DNA damage stimulus spliceosomal complex assembly protein ubiquitination proteasomal protein catabolic process transcription-coupled nucleotide-excision repair double-strand break repair via nonhomologous end joining DNA repair RNA splicing generation of catalytic spliceosome for first transesterification step positive regulation of neuron differentiation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 27339 28000 Ensembl ENSG00000110107 ENSMUSG00000024735 UniProt Q9UMS4 Q99KP6 RefSeq (mRNA) NM_014502 NM_001253843 NM_001253844 NM_134129 RefSeq (protein) NP_055317 NP_001240772 NP_001240773 NP_598890 Location (UCSC) Chr 11: 60.89 – 60.91 Mb Chr 19: 10.87 – 10.89 Mb PubMed search [3] [4]
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In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.[supplied by OMIM]^[6]