Palmitoylethanolamide
Chemical compound
From Wikipedia, the free encyclopedia
Palmitoylethanolamide (PEA), also known as palmidrol (INN), is an endogenous fatty acid amide, and lipid modulator.[2]
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| Names | |
|---|---|
| Preferred IUPAC name
N-(2-Hydroxyethyl)hexadecanamide[1] | |
Other names
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| Identifiers | |
3D model (JSmol) |
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| Abbreviations | PEA |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.008.062 |
| EC Number |
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| KEGG | |
| MeSH | palmidrol |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C18H37NO2 | |
| Molar mass | 299.499 g·mol−1 |
| Appearance | White crystals |
| Density | 910 mg mL−1 |
| Melting point | 93 to 98 °C (199 to 208 °F; 366 to 371 K) |
| log P | 5.796 |
| Hazards | |
| Flash point | 323.9 °C (615.0 °F; 597.0 K) |
| Related compounds | |
Related compounds |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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PEA is not a classic endocannabinoid because it lacks affinity for the cannabinoid receptors CB1 and CB2.[3][better source needed]
Metabolism
PEA is metabolized by the cellular enzymes fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amide hydrolase (NAAA), the latter of which has more specificity toward PEA over other fatty acid amides.[4]
Safety
PEA is generally considered safe, and without adverse drug reactions (ADRs) or drug interactions. A 2016 meta‐analysis of PEA as an analgesic concluded that for treatment periods up to 49 days, there were no serious ADRs at an incidence of 1/200 or greater.[5] Another meta-analysis found that no serious ADRs occurred.[6]