Piberaline

Chemical compound From Wikipedia, the free encyclopedia

Piberaline (EGYT-475; Trelibet) is a psychoactive drug and member of the piperazine chemical class which was developed in the 1980s. It has stimulant and antidepressant effects which are thought to be due largely to its active metabolite benzylpiperazine.[1] It was studied to a limited extent in Hungary and Spain, but was not widely accepted and does not seem to be in current use, although a closely related drug befuraline with similar effects has been slightly more successful.

Trade namesTrelibet
ATC code
  • none
Quick facts Clinical data, Trade names ...
Piberaline
Clinical data
Trade namesTrelibet
ATC code
  • none
Identifiers
  • [4-(Phenylmethyl)piperazin-1-yl]-pyridin-2-ylmethanone
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H19N3O
Molar mass281.359 g·mol−1
3D model (JSmol)
  • C1CN(CCN1CC2=CC=CC=C2)C(=O)C3=CC=CC=N3
  • InChI=1S/C17H19N3O/c21-17(16-8-4-5-9-18-16)20-12-10-19(11-13-20)14-15-6-2-1-3-7-15/h1-9H,10-14H2
  • Key:TZFUBYYADABEAV-UHFFFAOYSA-N
  (verify)
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Synthesis

Piberaline can be prepared by reaction of picolinic acid with benzylpiperazine.[2][3][4]

Synthesis of piberaline

Alternatively, it can be synthesized from 2-chloropyridine, carbon monoxide, and benzylpiperazine.

See also

References

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