Pacer (also known as Rubicon-like) is a protein that in humans is encoded by the RUBCNL gene.[5] Pacer has been shown to increase cellular autophagy through regulation of PI3KC3.[6]
AliasesRUBCNL, C13orf18, KIAA0226L, KIAA0226-like, KIAA0226 like, RUN and cysteine rich domain containing beclin 1 interacting protein like, PACER, rubicon like autophagy regulator, rubicon like autophagy enhancer Quick facts RUBCNL, Identifiers ...
| RUBCNL |
|---|
|
| Identifiers |
|---|
| Aliases | RUBCNL, C13orf18, KIAA0226L, KIAA0226-like, KIAA0226 like, RUN and cysteine rich domain containing beclin 1 interacting protein like, PACER, rubicon like autophagy regulator, rubicon like autophagy enhancer |
|---|
| External IDs | MGI: 2685590; GeneCards: RUBCNL |
|---|
|
|
|
|
| Wikidata |
|
Close
Pacer contains a Rubicon homology (RH) domain at its C-terminus, which mediates binding to small GTPase Rab7 when Rab7 is phosphorylated following mitochondrial damage.[7][5][8] This domain is shared with RH domain containing family members Rubicon and PLEKHM1.[9] Whereas Pacer appears to upregulate autophagic activity, Rubicon is a negative regulator of autophagy.[9]
