S-DMT

S-DMT
Clinical data
Other names	1-Thia-DMT; N,N-Dimethyl-3-(2-aminopropyl)benzo[β]thiophene; N,N-Dimethyl-3-AEBT
Drug class	Serotonin receptor modulator
ATC code	None;
Identifiers
	IUPAC name 2-(1-benzothiophen-3-yl)-N,N-dimethylethanamine;
CAS Number	10275-64-6;
PubChem CID	25118;
ChemSpider	23463;
CompTox Dashboard (EPA)	DTXSID80145488 ;
Chemical and physical data
Formula	C12H15NS
Molar mass	205.32 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCC1=CSC2=CC=CC=C21;
	InChI InChI=1S/C12H15NS/c1-13(2)8-7-10-9-14-12-6-4-3-5-11(10)12/h3-6,9H,7-8H2,1-2H3; Key:QAPUMUJBYRYLGE-UHFFFAOYSA-N;

S-DMT, also known as 1-thia-DMT or as N,N-dimethyl-3-(2-aminoethyl)benzo[β]thiophene (N,N-dimethyl-3-AEBT), is a serotonin receptor modulator of the benzothiophene family related to the psychedelic tryptamine dimethyltryptamine (DMT).^[1]^[2] It is the analogue and bioisostere of DMT in which the nitrogen atom of the indole ring has been replaced with a sulfur atom, making the drug a benzothiophene rather than indole or tryptamine derivative.^[2] The drug shows about the same activity at the serotonin receptors in the rat fundus strip as DMT.^[1]^[2]^[3]^[4] These receptors may correspond to the serotonin 5-HT_2B receptor.^[5]^[6] It has not been assessed at the serotonin 5-HT_2A receptor.^[1] S-DMT was first described in the scientific literature by Richard Glennon and colleagues by 1979.^[1]^[2]