S. Murty Srinivasula

Born1963 (age 62–63)

Almamater

KnownforStudies on novel regulators of Apoptosis and Autophagy

FieldsBiology, cell biology, apoptosis, autophagy

Prof. S. Murty Srinivasula
Prof. S. Murty Srinivasula
Born	1963 (age 62–63)
Alma mater	Banaras Hindu University Andhra University National Cancer Institute Thomas Jefferson University Einstein Medical Center Philadelphia
Known for	Studies on novel regulators of Apoptosis and Autophagy
Scientific career
Fields	Biology, cell biology, apoptosis, autophagy
Institutions	Indian Institute of Science Education and Research, Thiruvananthapuram National Cancer Institute

Srinivasa Murty Srinivasula is an Indian cell biologist, a professor at the School of Biology at the Indian Institute of Science Education and Research, Thiruvananthapuram (IISER Thiruvananthapuram) in Kerala, India. His research field is apoptosis, autophagy and oncology.^[1]^[2]

Professor Murty received his B.Sc and M.Sc degrees from the Andhra University and his PhD from the Banaras Hindu University in Varanasi, India. He later moved to the Thomas Jefferson University as a research associate and became an instructor at the Sidney Kimmel Cancer Center at Thomas Jefferson University in Philadelphia, United States. During 2003–2012, he was the principal investigator at National Cancer Institute, NIH, Bethesda.^[3]^[4] He was Professor-in-charge (administration) at the IISER Thiruvananthapuram,^[5]^[6] as well as the member of the IISER TVM Senate.^[7] He also served on several institute committees.^[8]^[9]^[10]^[11] Currently he is Deputy Director of the institute.^[12]

Key awards and distinctions

Professor Murty has received the following awards:

Kimmel Scholar (2003-2005), The Sidney Kimmel Foundation for Cancer Research, Baltimore, MD^[13]
Special Fellow (2000-2003), The Leukemia and Lymphoma Society, New York, NY
Young Scientist Travel Award, American Association for Cancer Research, Inc. Philadelphia
Research Fellowships (1987-1992), University Grants Commission (India)
National Merit Scholarships (1984 -1986), Department of Education, Government of India, New Delhi

Publications

Professor Murty has published around 100 papers and reviews in international scientific journals.^[14]

Key publications

Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D. (2012). PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα (12). Nat. Cell Biol^[15]
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997). Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade. Cell, 91(4), 479–489.^[16]
Fujita K and Srinivasula SM. (2011). TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS). Autophagy, 7: 29–31.^[17]
Fujita K, Xiao Q, Maeda D and Srinivasula SM. (2011). Nrf2-mediated induction of p62 controls TLR4-driven ALIS formation and autophagic degradation, Proc Nat Acad Sci, USA, 108: 1427–32.^[18]
Shukla S, Fujita K, Xiao Q, and Srinivasula SM. (2011). A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface. Apoptosis, 16: 162–173.^[19]
Liao, W, Fujita K, Xiao Q, Tchikov V, Yang W, Gunsor, M, Garfield S, Goldsmith, P. El-Deiry WS, Schutze S, and Srinivasula SM. (2009). CARP1 Regulates Induction of NF-κB by TNF-a. Current Biology. 19: R17-R19^[20]
Liao, W, Xiao Q, Tchikov V, Fujita K, Yang W, Wincovitch S, Garfield S, Schutze S, El-Deiry WS, and Srinivasula SM. (2008). CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-?B activation. Current Biology (article). 18: 641–9.^[21]
Srinivasula SM, Jones JM., Datta P., Ji W., Gupta S., Zhang Z., Davies E., Hajnóczky G., Saunders TL., Van Keuren ML., Alnemri T., Meisler ML and Alnemri ES. (2003). Loss of Omi/HtrA2 protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature. 425: 721–727.^[22]
Srinivasula SM, Datta P, Kobayashi M, Wu J-W, Fujioka M, Hegde R, Zhang Z, Mukattash, Fernandes-Alnemri T, Shi Y, Jaynes JB, Alnemri ES. (2002). Sickle, a novel Drosophila death gene in the reaper/hid/grim region encodes an IAP-inhibitory protein. Curr Biol. 12: 125–30.^[23]
Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA., Robbins PD, Fernandes-Alnemri T, Shi Y., Alnemri ES. (2001). A conserved XIAP-interaction motif in caspase-9 and Smac/Diablo regulates caspase activity and apoptosis. Nature. 410: 112–16.^[24]
Srinivasula SM, Saleh A, Balkir L, Robbins PD, and Alnemri ES. (2000). Negative regulation of the Apaf-1 apoptosome by Hsp70. Nature Cell Biol 2: 476–483.^[25]

Book chapters

Fujita, K and Srinivasula SM. (2009). Ubiquitination and Death-receptor signaling. Death Receptors and Cognate Ligands in Cancer. Results Probl Cell Differ, SpringerLinks Publisher. 49: 87-114.^[26]
Srinivasula SM, Saleh A, Ahmad M, Fernandes-Alnemri T, Alnemri ES. (2001). Isolation and Assay of Caspases. Ch. 1. Methods in Cell Biol. 66:1-27.^[27]

v t e Scientific Research in Kerala
Pre 19th Century	Achyuta Pisharati Candravakyas Citrabhanu Damodara Ganita-yukti-bhasa Govinda Bhattathiri Haridatta Jyā, koti-jyā and utkrama-jyā Jyeṣṭhadeva Jyotirmimamsa Karanapaddhati Katapayadi system Kriyakramakari Madhava of Sangamagrama Madhava series Madhava's sine table Melpathur Narayana Bhattathiri Nilakantha Somayaji Parameshvara Sadratnamala Śaṅkaranārāyaṇa Tantrasamgraha
Organizations	C-DAC Thiruvananthapuram Centre for Development Studies Centre for Earth Science Studies Centre for Mathematical Sciences (Kerala) Centre for Rural Management Centre of Science and Technology for Rural Development Cyberpark Kerala Mathematical Association Kerala Science and Technology Museum Kerala Science Congress Kerala Soil Museum Kerala State Council for Science, Technology and Environment Krishi Vigyan Kendra Kannur Liquid Propulsion Systems Centre Rajiv Gandhi Centre for Biotechnology Regional Agricultural Research Station, Pattambi Rice Research Station, Moncombu Vikram Sarabhai Space Centre
Institutions	Agricultural Research Station, Anakkayam Agricultural Research Station, Mannuthy Agronomic Research Station, Chalakudy Amrita Institute of Medical Sciences and Research Centre Aromatic and Medicinal Plants Research Station, Odakkali Banana Research Station, Kannara Cashew Research Station, Madakkathara Central Institute of Fisheries Technology Central Marine Fisheries Research Institute Central Tuber Crops Research Institute Centre for Marine Living Resources & Ecology College of Horticulture Crocodile Rehabilitation and Research Centre Institute of Handloom and Textile Technology Indian Institute of Science Education and Research, Thiruvananthapuram Indian Institute of Space Science and Technology Indian Institute of Spices Research Jubilee Mission Medical College and Research Institute Kerala Forest Research Institute Kerala School of Mathematics, Kozhikode Mar Athanasios College for Advanced Studies, Tiruvalla National Institute for Interdisciplinary Science and Technology National Institute of Speech and Hearing National Research Institute for Panchakarma Naval Physical and Oceanographic Laboratory Oriental Research Institute & Manuscripts Library Sree Chitra Tirunal Institute for Medical Sciences and Technology Srinivasa Ramanujan Institute of Basic Sciences St. Ephrem Ecumenical Research Institute Tropical Botanical Garden and Research Institute Vadakke Madham Brahmaswam Vedic Research Centre
Scientists	Ajit Varki C. V. Subramanian Dileep George E. C. George Sudarshan G. Madhavan Nair George Varghese K. R. Ramanathan K. Radhakrishnan M. G. K. Menon Matthew Pothen Thekaekara P. N. Vinayachandran Pisharoth Rama Pisharoty Pulickel Ajayan R. S. Krishnan Sainudeen Pattazhy T. A. Venkitasubramanian Thanu Padmanabhan Thomas Zacharia Vainu Bappu Varghese Mathai Vinod Scaria
Assorted articles	A Passage to Infinity FORV Sagar Sampada Swatantra 2014 Techno-lodge Technology Business Incubator TBI-NITC A History of the Kerala School of Hindu Astronomy
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S. Murty Srinivasula

Key awards and distinctions

Publications

Key publications

Book chapters

External links

References

Related Articles

Related Articles

"PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12"

"TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS)"

"Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation"

"A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface"

"CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation"

"sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein"

"Chapter 1 Isolation and assay of caspases"