SF1 (gene)

Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene.^[4][5][6]

PDBOrtholog search: PDBe RCSB

AliasesSF1, BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162, splicing factor 1

External IDsOMIM: 601516; MGI: 1095403; HomoloGene: 138518; GeneCards: SF1; OMA:SF1 - orthologs

Chr.Chromosome 11 (human)^[1]

Quick facts Available structures, PDB ...

SF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K1G, 1O0P, 1OPI, 2M09, 4FXW, 4FXX
Identifiers
Aliases	SF1, BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162, splicing factor 1
External IDs	OMIM: 601516; MGI: 1095403; HomoloGene: 138518; GeneCards: SF1; OMA:SF1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 64,764,606 bp[1] End 64,778,786 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left ovary tibial nerve gastric mucosa right ovary right lobe of thyroid gland left uterine tube canal of the cervix right hemisphere of cerebellum left lobe of thyroid gland n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity zinc ion binding metal ion binding protein binding nucleic acid binding identical protein binding pre-mRNA branch point binding RNA binding Cellular component ribosome spliceosomal complex nucleus nucleoplasm nuclear body Biological process negative regulation of smooth muscle cell proliferation regulation of transcription, DNA-templated Leydig cell differentiation mRNA processing regulation of steroid biosynthetic process male sex determination transcription, DNA-templated spliceosomal complex assembly mRNA 3'-splice site recognition RNA splicing negative regulation of nucleic acid-templated transcription mRNA splicing, via spliceosome nuclear body organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7536 22668 Ensembl ENSG00000168066 ENSMUSG00000024949 UniProt Q15637 Q64213 RefSeq (mRNA) NM_001178030 NM_001178031 NM_004630 NM_201995 NM_201997 NM_201998 NM_001346363 NM_001346364 NM_001346409 NM_001346410 NM_001378956 NM_001378957 NM_001110791 NM_011750 RefSeq (protein) NP_001171501 NP_001171502 NP_001333292 NP_001333293 NP_001333338 NP_001333339 NP_004621 NP_973724 NP_973726 NP_973727 NP_001365885 NP_001365886 NP_001104261 NP_035880 NP_001347322 NP_001390363 NP_001390364 NP_001390365 NP_001390368 NP_001390369 NP_001390370 NP_001390371 NP_001390372 NP_001390373 NP_001390374 NP_001390375 NP_001390376 NP_001390377 NP_001390378 Location (UCSC) Chr 11: 64.76 – 64.78 Mb n/a PubMed search [2] [3]
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Splicing factor SF1 is involved in the ATP-dependent formation of the spliceosome complex.^[7]