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Transcription elongation regulator 1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.[5][6][7]

AliasesTCERG1, CA150, TAF2S, Urn1, transcription elongation regulator 1
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TCERG1
Identifiers
AliasesTCERG1, CA150, TAF2S, Urn1, transcription elongation regulator 1
External IDsOMIM: 605409; MGI: 1926421; GeneCards: TCERG1
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040006
NM_006706
NM_001382548

NM_001039474
NM_001289526
NM_001360881
NM_019512

RefSeq (protein)

NP_001035095
NP_006697
NP_001369477

NP_001034563
NP_001276455
NP_001347810

Location (UCSC)Chr 5: 146.45 – 146.51 MbChr 18: 42.64 – 42.71 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.[5]

Interactions

Transcription elongation regulator 1 has been shown to interact with SF1[8] and POLR2A.[9]

References

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