SMARCB1

SMARCB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5AJ1
Identifiers
Aliases	SMARCB1, BAF47, INI1, MRD15, PPP1R144, RDT, RTPS1, SNF5, SNF5L1, SWNTS1, Sfh1p, Snr1, hSNFS, CSS3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1, INI-1
External IDs	OMIM: 601607; MGI: 1328366; HomoloGene: 2310; GeneCards: SMARCB1; OMA:SMARCB1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	23,838,009 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,757,451 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; right hemisphere of cerebellum; ; stromal cell of endometrium; ; olfactory zone of nasal mucosa; ; islet of Langerhans; ; left testis; ; left ovary; ; right testis; ; right ovary;
	Top expressed in
	Rostral migratory stream; ; ventricular zone; ; ganglionic eminence; ; external carotid artery; ; internal carotid artery; ; epiblast; ; Paneth cell; ; Ileal epithelium; ; embryo; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; RNA polymerase I core promoter sequence-specific DNA binding; transcription coactivator activity; p53 binding; Tat protein binding; protein binding; nucleosomal DNA binding;
Cellular component	nucleoplasm; nuclear chromosome; nucleolus; nucleus; fibrillar center; intracellular membrane-bounded organelle; SWI/SNF complex; npBAF complex; nBAF complex; protein-containing complex; brahma complex;
Biological process	positive regulation of glucose mediated signaling pathway; chromatin remodeling; regulation of transcription, DNA-templated; DNA integration; positive regulation of histone H3-K9 acetylation; regulation of transcription by RNA polymerase II; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; positive regulation of DNA-binding transcription factor activity; transcription, DNA-templated; nervous system development; nucleosome disassembly; positive regulation of histone H4 acetylation; single stranded viral RNA replication via double stranded DNA intermediate; cell cycle; negative regulation of histone H3-K9 trimethylation; regulation of histone H4-K16 acetylation; viral process; negative regulation of histone H3-K9 dimethylation; DNA repair; positive regulation by host of viral transcription; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; cell differentiation; RNA polymerase I preinitiation complex assembly; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	6598
	20587
	ENSG00000099956; ENSG00000275837
	ENSMUSG00000000902
	Q12824
	Q9Z0H3
	NM_001007468; NM_003073; NM_001317946; NM_001362877
	NM_001161853; NM_011418
	NP_001007469; NP_001304875; NP_003064; NP_001349806
	NP_001155325; NP_035548
	Wikidata
View/Edit Human	View/Edit Mouse

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.^[5]^[6]^[7]

PDBOrtholog search: PDBe RCSB

AliasesSMARCB1, BAF47, INI1, MRD15, PPP1R144, RDT, RTPS1, SNF5, SNF5L1, SWNTS1, Sfh1p, Snr1, hSNFS, CSS3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1, INI-1

External IDsOMIM: 601607; MGI: 1328366; HomoloGene: 2310; GeneCards: SMARCB1; OMA:SMARCB1 - orthologs

Chr.Chromosome 22 (human)^[1]

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[6]

[7]

[1]

[2]

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SMARCB1

Function

Interactions

References

Further reading

External links

Related Articles

Related Articles

"Purification and biochemical heterogeneity of the mammalian SWI-SNF complex"

"A human RNA polymerase II complex containing factors that modify chromatin structure"

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"Transcriptional activation domains of human heat shock factor 1 recruit human SWI/SNF"

"A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: implications for tumorigenesis"

"Cellular co-factors of HIV-1 integration"

"A human protein with homology to Saccharomyces cerevisiae SNF5 interacts with the potential helicase hbrm"

"Epstein-Barr virus nuclear protein 2 (EBNA2) binds to a component of the human SNF-SWI complex, hSNF5/Ini1"

"Structure-function analysis of integrase interactor 1/hSNF5L1 reveals differential properties of two repeat motifs present in the highly conserved region"

"Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers"