SW033291

SW033291
Clinical data
Drug class	15-PGDH inhibitor
Identifiers
	IUPAC name 2-butylsulfinyl-4-phenyl-6-thiophen-2-yl-1-benzothiophen-3-amine;
CAS Number	459147-39-8 ; 1714961-54-2 (R enantiomer);
PubChem CID	117944082;
Chemical and physical data
Formula	C22H21NOS3
Molar mass	411.60 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCS(=O)C1=C(C2=C(C=C(C=C2S1)C3=CC=CS3)C4=CC=CC=C4)N;
	InChI InChI=1S/C22H21NOS3/c1-2-3-12-27(24)22-21(23)20-17(15-8-5-4-6-9-15)13-16(14-19(20)26-22)18-10-7-11-25-18/h4-11,13-14H,2-3,12,23H2,1H3; Key:KLWRXRJDKBUYCJ-UHFFFAOYSA-N;

Drug class15-PGDH inhibitor

FormulaC₂₂H₂₁NOS₃

SW033291 (PGDHi) is a drug which acts as a potent inhibitor of the enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH). The (R) or (+) enantiomer is more active, though much of the earlier research used the racemic mix. It increases levels of prostaglandin E2 and promotes tissue regeneration, and has shown beneficial effects for numerous potential medical applications in animal studies, including recovery from bone marrow transplant,^[1]^[2]^[3] acute kidney injury,^[4]^[5] liver damage,^[6] diabetes,^[7] heart failure,^[8]^[9] cartilage regrowth,^[10] sarcopenia,^[11]^[12]^[13] and neurological conditions such as Alzheimer's disease and traumatic brain injury.^[14]

References