SW209415

SW209415
Clinical data
Drug class	15-PGDH inhibitor
Identifiers
	IUPAC name (R)-2-(butylsulfinyl)-4-(1,2-dimethyl-1H-imidazol-5-yl)-6-(thiazol-2-yl)thieno[2,3-b]pyridin-3-amine;
PubChem CID	129281194;
ChemSpider	76789060;
ChEMBL	ChEMBL4070789;
Chemical and physical data
Formula	C19H21N5OS3
Molar mass	431.59 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cn1c(cnc1C)c1cc(nc2sc([S@](=O)CCCC)c(N)c21)c1sccn1;
	InChI InChI=1S/C19H21N5OS3/c1-4-5-8-28(25)19-16(20)15-12(14-10-22-11(2)24(14)3)9-13(23-18(15)27-19)17-21-6-7-26-17/h6-7,9-10H,4-5,8,20H2,1-3H3/t28-/m1/s1; Key:LKPKDKDBZLBUIC-MUUNZHRXSA-N;

Drug class15-PGDH inhibitor

PubChem CID

129281194

ChemSpider

76789060

ChEMBL

ChEMBL4070789

SW209415 is a drug that acts as a potent inhibitor of the enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH), which increases levels of prostaglandin E2 and promotes tissue regeneration. The (R) or (+) enantiomer is the more active. It has similar potency in vitro to the earlier and better studied related compound SW033291, but its solubility is far higher and its pharmacokinetic properties and bioavailability significantly improved, making it more suitable for development for potential clinical applications. It is being researched for improved healing of broken bones and accelerating recovery from bone marrow transplant.^[1]^[2]^[3]^[4]

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