Salubrinal

Salubrinal is a drug which acts as a specific inhibitor of eIF2α phosphatase enzymes^[1][2][3] and is primarily used experimentally, to study stress responses in eukaryotic cells associated with the action of eIF2. Salubrinal indirectly inhibits eIF2 as a result of reduced dephosphorylation of its α-subunit,^[4] resulting in activation of stress response pathways usually triggered by events such as oxidative stress or buildup of unfolded protein in the endoplasmic reticulum.^[5] Salubrinal has putative therapeutic value due to its function,^[1][3] but is as yet only used experimentally. Salubrinal is being studied at Indiana University for its potential to fight osteoporosis and accelerate bone healing.^[6]

CAS Number

• 405060-95-9 ^Y

PubChem CID

• 5717801

ChemSpider

• 4654442 ^N

UNII

• J8PSF5Z8KJ

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Salubrinal

Identifiers
IUPAC name 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
CAS Number	405060-95-9 Y
PubChem CID	5717801
ChemSpider	4654442 N
UNII	J8PSF5Z8KJ
ChEBI	CHEBI:131923 N
ChEMBL	ChEMBL180127 N
CompTox Dashboard (EPA)	DTXSID70420852
ECHA InfoCard	100.237.268
Chemical and physical data
Formula	C21H17Cl3N4OS
Molar mass	479.80 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC=C(C=C1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3
InChI InChI=1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+ N Key:LCOIAYJMPKXARU-VAWYXSNFSA-N N
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