Before Western contact in the late 18th century, the Cape Scott area was inhabited by three Kwakwakaʼwakw indigenous peoples, Nakomgilisala (Nakomgilisala), Koskimo and Quatsino. By the early 19th century the Yutlinuk of the nearby Scott Islands had ceased to exist as a separate people, with survivors merging with the Tlatlasikwala at the village of Nahwitti near Cape Sutil on the northeastern shore of Vancouver Island at the mouth of the Nahwitti River, and at the village of Humdaspe on Hope Island, and further south the Kwaguilth village of Tsaxis beside the Hudson's Bay Company outpost of Fort Rupert. In the mid-1850s the Tlatlasikwala and Nakumgilisala merged and moved to Hope Island, where they remained until 1954, at which time their population had dropped to just 32 individuals. In 1954 they joined with the Koskimo (Quatsino) people and moved to the Quatsino Sound area.[22] Before 1985 they were known as the Nuwitti or Nahwitti, and today Tlatlasikwala.[23]
The Koskimo and the Nakomgilisila were traditionally a closely related group of families (namima) of one tribe prior to contact. Both groups have tribal ancestor origin stories for areas around Nels Bight and the mouth of the Strandby River just west of Cape Scott at an ancient village known as Kosaa. The Koskimo moved south to Quatsino Sound during proto-historic times or very early in the maritime fur trade period. The San Josef Bay area was traditionally Quatsino territory with Quatsino origin stories naming San Josef Bay as a place where their ancestors first emerged. By the later 19th century, the Semach Indian Reserve was created in Sea Otter Cove for the Nahwitti tribe who assuredly were using this site due to their connections to the Nakomgilisila tribe.[24]
The area was visited by two of the first maritime fur traders, who were among the earliest Western visitors to the Pacific Northwest coast after Captain James Cook. The first maritime fur trading ship captain to visit the coast, James Hanna, traded for sea otter furs at Nootka Sound in 1785 and made a considerable profit. His backers funded a second voyage in 1786, but when Hanna arrived at Nootka Sound he discovered that a second maritime fur trader, James Strange, had already been there and collected most of the sea otter furs available. So Hanna sailed Sea Otter north, in the process finding San Josef Bay. He named it St. Patrick's Bay. This name survives as the name of Mount St. Patrick on the northern shore of the bay. Hanna also gave Sea Otter Cove its present name, after his ship Sea Otter.[25]
James Strange also sailed north from Nootka Sound, finding San Josef Bay as well and naming it Scott's Bay, a name which survives in some nearby place names, such as Cape Scott. By the 1790s, as the maritime fur trade boomed, indigenous peoples of the Pacific Northwest Coast focused the trade to certain places by bringing sea otter furs from a large area to a central trading site. For the San Josef Bay area, which was Kwakwakaʼwakw territory, this trading site was Nahwitti, around Cape Scott on the northernmost coast of Vancouver Island. Nahwitti was under the control of the Kwakwakaʼwakw Tlatlasikwala Nation.
San Josef Bay, and nearby areas like Sea Otter Cove, were prime sea otter habitat. By the early 19th century sea otters had been hunted to local extinction.