Scianna antigen system
From Wikipedia, the free encyclopedia
Scianna blood group antigens are carried on the ERMAP protein, a single-pass transmembrane glycoprotein encoded by the ERMAP gene (erythroblast membrane-associated protein).[3][4][5] Clinical testing in patient care for ERMAP follows published minimum quality and operational requirements,[6] similar to red cell genotyping for any of the other recognized blood group systems. Molecular analysis can identify gene variants (alleles) that may affect ERMAP protein expression on the red cell membrane.
History
This blood group system was discovered in 1962 when a high frequency antigen was detected in a young woman (Ms. Scianna) who had experienced several late pregnancy losses due to haemolytic disease of the fetus.[4] In 2003, ERMAP was established as the gene underlying the Scianna blood group system.[7] Scianna was the last of the previously characterized protein-based blood group systems whose molecular basis was elucidated.
References
- 1 2 3 "Scianna Blood Group System", Human Blood Groups, Wiley-Blackwell, 2013-01-28, pp. 371–375, doi:10.1002/9781118493595.ch13, ISBN 9781118493595
- ↑ "Table of blood group systems" (PDF). ISBT. Retrieved 24 June 2019.
- ↑ Su YY, Gordon CT, Ye TZ, Perkins AC, Chui DH (2001). "Human ERMAP: an erythroid adhesion/receptor transmembrane protein". Blood Cells Mol Dis. 27 (5). doi:10.1006/bcmd.2001.0465. PMID 11783959.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - 1 2 Brunker, Patricia; Flegel, Willy (2011). "Scianna: the lucky 13th blood group system". Immunohematology. 27 (2): 41–57. doi:10.21307/immunohematology-2019-173. PMC 5189634. PMID 22356519.
- ↑ Wagner, F. F.; Poole, Joyce; Flegel, Willy (2003-01-15). "Scianna antigens including Rd are expressed by ERMAP". Blood. 101 (2): 752–757. doi:10.1182/blood-2002-07-2064. PMID 12393480.
- ↑ Standards for Molecular Testing for Red Cell, Platelet, and Neutrophil Antigens (7 ed.). Association for the Advancement of Blood & Biotherapies. January 1, 2025. ISBN 978-1-56395-516-7.
- ↑ Wagner, FF; Poole, J; Flegel, WA (15 January 2003). "Scianna antigens including Rd are expressed by ERMAP". Blood. 101 (2): 752–7. doi:10.1182/blood-2002-07-2064. PMID 12393480.
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