Senicapoc

Senicapoc (ICA-17043) is a Gardos channel blocker.^[1][2]

Quick facts Names, Identifiers ...

Senicapoc

Names
Preferred IUPAC name 2,2-Bis(4-fluorophenyl)-2-phenylacetamide
Identifiers
CAS Number	289656-45-7 Y
3D model (JSmol)	Interactive image
ChemSpider	187516 N
IUPHAR/BPS	2331
KEGG	D06640 Y
PubChem CID	216327
UNII	TS6G201A6Q Y
CompTox Dashboard (EPA)	DTXSID60276906
InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24) N Key: SCTZUZTYRMOMKT-UHFFFAOYSA-N N InChI=1/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24) Key: SCTZUZTYRMOMKT-UHFFFAOYAR
SMILES C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N
Properties
Chemical formula	C20H15F2NO
Molar mass	323.34 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

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It has been proposed for use in sickle cell anemia.^[3] Gardos channel blockers may work in the treatment of sickle cell anemia by blocking the efflux of potassium and water from red blood cells, thereby preventing the dehydration of red blood cells and stopping the polymerization of HbS.

The Gardos channel has been identified as KCNN4.^[4]

The "ICA" is for Icagen, which is developing the drug.^[5]