Serlopitant

Serlopitant
Clinical data
Routes of; administration	By mouth
ATC code	None;
Identifiers
	IUPAC name 3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-4-(4-fluorophenyl)octahydro-2H-isoindol-2-yl]cyclopent-2-en-1-one;
CAS Number	860642-69-9;
PubChem CID	23653789;
ChemSpider	24686685;
UNII	277V92K32B;
KEGG	D09378;
ChEMBL	ChEMBL447955;
CompTox Dashboard (EPA)	DTXSID701006599 ;
Chemical and physical data
Formula	C29H28F7NO2
Molar mass	555.537 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@H]2CC[C@@H]3CN(C[C@H]3[C@@H]2C4=CC=C(C=C4)F)C5=CC(=O)CC5;
	InChI InChI=1S/C29H28F7NO2/c1-16(19-10-20(28(31,32)33)12-21(11-19)29(34,35)36)39-26-9-4-18-14-37(23-7-8-24(38)13-23)15-25(18)27(26)17-2-5-22(30)6-3-17/h2-3,5-6,10-13,16,18,25-27H,4,7-9,14-15H2,1H3/t16-,18-,25-,26+,27+/m1/s1; Key:FLNYCRJBCNNHRH-OIYLJQICSA-N;

Routes of
administrationBy mouth

ATC code

None

CAS Number

860642-69-9

PubChem CID

23653789

Serlopitant (INN,^[1] codenamed VPD-737) is a drug which acts as an NK₁ receptor antagonist. It was assessed in clinical trials for the treatment of urinary incontinence and overactive bladder, but while it was superior to placebo it provided no advantage over existing approved drugs, and was not approved for further development for this indication.^[2]^[3] Serlopitant is now undergoing clinical trials for the treatment of chronic pruritus (itch)^[4]

[1]

[2]

[3]

[4]

v t e Neurokinin receptor modulators
NK₁	Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743,310 L-758,298 Lanepitant LY-306740 Maropitant Netupitant NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant
NK₂	Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide
NK₃	Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant

Serlopitant

References

Related Articles

Clinical data

Routes of administration	By mouth
ATC code	None
Identifiers
IUPAC name 3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-4-(4-fluorophenyl)octahydro-2H-isoindol-2-yl]cyclopent-2-en-1-one
CAS Number	860642-69-9
PubChem CID	23653789
ChemSpider	24686685
UNII	277V92K32B
KEGG	D09378
ChEMBL	ChEMBL447955
CompTox Dashboard (EPA)	DTXSID701006599
Chemical and physical data
Formula	C₂₉H₂₈F₇NO₂
Molar mass	555.537 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@H]2CC[C@@H]3CN(C[C@H]3[C@@H]2C4=CC=C(C=C4)F)C5=CC(=O)CC5
InChI InChI=1S/C29H28F7NO2/c1-16(19-10-20(28(31,32)33)12-21(11-19)29(34,35)36)39-26-9-4-18-14-37(23-7-8-24(38)13-23)15-25(18)27(26)17-2-5-22(30)6-3-17/h2-3,5-6,10-13,16,18,25-27H,4,7-9,14-15H2,1H3/t16-,18-,25-,26+,27+/m1/s1 Key:FLNYCRJBCNNHRH-OIYLJQICSA-N