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Sjögren syndrome antigen B

Protein From Wikipedia, the free encyclopedia

Sjögren syndrome type B antigen (SS-B) also known as Lupus La protein is a protein that in humans is encoded by the SSB gene.[5]

AliasesSSB, LARP3, La, La/Sjogren syndrome antigen B, small RNA binding exonuclease protection factor La
PDBOrtholog search: PDBe RCSB
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SSB
Identifiers
AliasesSSB, LARP3, La, La/Sjogren syndrome antigen B, small RNA binding exonuclease protection factor La
External IDsOMIM: 109090; MGI: 98423; HomoloGene: 2366; GeneCards: SSB; OMA:SSB - orthologs
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003142
NM_001294145

NM_001110145
NM_009278
NM_001355265

RefSeq (protein)

NP_001281074
NP_003133

NP_001103615
NP_033304
NP_001342194

Location (UCSC)Chr 2: 169.79 – 169.81 MbChr 2: 69.69 – 69.7 Mb
PubMed search[3][4]
Wikidata
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Function

La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjögren's syndrome and systemic lupus erythematosus.[5][6]

Interactions

Sjögren syndrome antigen B has been shown to interact with nucleolin.[7]

See also

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