TAL1

TAL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YPA, 2YPB
Identifiers
Aliases	TAL1, SCL, TCL5, bHLHa17, tal-1, T-cell acute lymphocytic leukemia 1, TAL bHLH transcription factor 1, erythroid differentiation factor
External IDs	OMIM: 187040; MGI: 98480; HomoloGene: 2400; GeneCards: TAL1; OMA:TAL1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	47,232,225 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	114,928,952 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; monocyte; ; bone marrow; ; right lung; ; endothelial cell; ; blood; ; upper lobe of left lung; ; bone marrow cell; ; buccal mucosa cell; ; epithelium of colon;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; tibiofemoral joint; ; blood; ; human fetus; ; embryo; ; spleen; ; endocardial cushion; ; bone marrow; ; yolk sac; ; genital tubercle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein dimerization activity; DNA-binding transcription factor activity; histone deacetylase binding; chromatin binding; transcription cis-regulatory region binding; E-box binding; protein binding; protein heterodimerization activity; enzyme binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	histone deacetylase complex; transcription regulator complex; Lsd1/2 complex; nucleus; nucleoplasm; protein-containing complex;
Biological process	megakaryocyte development; megakaryocyte differentiation; myeloid cell differentiation; cell fate commitment; cell differentiation; regulation of transcription, DNA-templated; regulation of mast cell differentiation; spinal cord association neuron differentiation; positive regulation of protein-containing complex assembly; locomotory behavior; positive regulation of erythrocyte differentiation; regulation of transcription by RNA polymerase II; regulation of stem cell population maintenance; platelet formation; positive regulation of mitotic cell cycle; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; generation of neurons; basophil differentiation; positive regulation of transcription, DNA-templated; multicellular organism development; regulation of cell population proliferation; hematopoietic stem cell differentiation; astrocyte fate commitment; angiogenesis; neuron differentiation; embryonic hemopoiesis; erythrocyte differentiation; definitive hemopoiesis; regulation of myeloid cell differentiation; positive regulation of cell division; hemangioblast cell differentiation; positive regulation of transcription by RNA polymerase II; erythrocyte maturation; regulation of hematopoietic stem cell differentiation; hemopoiesis; transcription by RNA polymerase II; negative regulation of erythrocyte differentiation; positive regulation of protein tyrosine kinase activity; positive regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	6886
	21349
	ENSG00000162367
	ENSMUSG00000028717
	P17542
	P22091
NM_001287347; NM_001290403; NM_001290404; NM_001290405; NM_001290406;
	NM_003189
	NM_011527; NM_001287388
NP_001274276; NP_001277332; NP_001277333; NP_001277334; NP_001277335;
	NP_003180
	NP_001274317; NP_035657
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene.^[5]^[6]