TB-500

From Wikipedia, the free encyclopedia

CAS Number
PubChem CID
ChemSpider
UNII
TB-500
The structure of TB-500.
Identifiers
  • (2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoic acid
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC38H68N10O14
Molar mass889.018 g·mol−1
3D model (JSmol)
  • C[C@H]([C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)C)O
  • InChI=1S/C38H68N10O14/c1-19(2)18-27(42-22(5)51)35(58)44-23(10-6-8-16-39)32(55)43-24(11-7-9-17-40)33(56)47-30(20(3)49)36(59)45-25(13-15-29(53)54)34(57)48-31(21(4)50)37(60)46-26(38(61)62)12-14-28(41)52/h19-21,23-27,30-31,49-50H,6-18,39-40H2,1-5H3,(H2,41,52)(H,42,51)(H,43,55)(H,44,58)(H,45,59)(H,46,60)(H,47,56)(H,48,57)(H,53,54)(H,61,62)/t20-,21-,23+,24+,25+,26+,27+,30+,31+/m1/s1
  • Key:ADKDNDYYIZUVCZ-ZQNQAVPYSA-N

TB-500 (Ac-LKKTETQ) is a synthetic heptapeptide that corresponds to the N-acetylated active fragment (amino acids 17–23)[1] of the endogenous signalling factor thymosin beta-4.[2] It is claimed to increase muscle growth and accelerate wound healing and tissue repair,[3] reduce inflammation, and improve flexibility.[4][5]

It has been encountered as a designer drug mainly in racehorses,[6] but is also prohibited for use by athletes in competition by the World Anti-Doping Agency, and is classified as a prescription medicine in some jurisdictions such as Australia and New Zealand.[7]

References

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