Thyroid hormone receptor beta

THRB
Identifiers
Aliases	THRB, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, thyroid hormone receptor beta, TRbeta
External IDs	OMIM: 190160; MGI: 98743; GeneCards: THRB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BSX, 1N46, 1NAX, 1NQ0, 1NQ1, 1NQ2, 1NUO, 1Q4X, 1R6G, 1XZX, 1Y0X, 2J4A, 2NLL, 2PIN, 3D57, 3GWS, 3IMY, 3JZC, 4ZO1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	24,495,756 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	4,809,435 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; tibia; ; postcentral gyrus; ; endothelial cell; ; superior frontal gyrus; ; entorhinal cortex; ; Achilles tendon; ; lactiferous duct; ; parotid gland;
	Top expressed in
	auditory system; ; spiral ganglion; ; neural layer of retina; ; organ of Corti; ; right kidney; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; muscle of thigh; ; proximal tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; transcription corepressor activity; zinc ion binding; metal ion binding; steroid hormone receptor activity; protein binding; enzyme binding; chromatin DNA binding; thyroid hormone binding; DNA-binding transcription factor activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription factor binding; nuclear receptor coactivator activity; signaling receptor activity; nuclear receptor activity;
Cellular component	nucleoplasm; nucleus; nuclear body; RNA polymerase II transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; regulation of heart contraction; female courtship behavior; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; hearing; type I pneumocyte differentiation; negative regulation of female receptivity; animal organ morphogenesis; transcription initiation from RNA polymerase II promoter; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; steroid hormone mediated signaling pathway; intracellular receptor signaling pathway; transcription, DNA-templated; negative regulation of eye photoreceptor cell development; retinal cone cell development; retinal cone cell apoptotic process; multicellular organism development; hormone-mediated signaling pathway; cell differentiation; thyroid gland development; response to lipid; thyroid hormone mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	7068
	21834
	ENSG00000151090
	ENSMUSG00000021779
	P10828
	P37242
NM_000461; NM_001128176; NM_001128177; NM_001252634; NM_001354708;
	NM_001354709; NM_001354710; NM_001354711; NM_001354712; NM_001354713; NM_001354714; NM_001354715; NM_001374822; NM_001374823; NM_001374824; NM_001374825; NM_001374826; NM_001374827
	NM_001113417; NM_009380
NP_000452; NP_001121648; NP_001121649; NP_001239563; NP_001341637;
	NP_001341638; NP_001341639; NP_001341640; NP_001341641; NP_001341642; NP_001341643; NP_001341644; NP_001361751; NP_001361752; NP_001361753; NP_001361754; NP_001361755; NP_001361756
	NP_001106888; NP_033406
	Wikidata
View/Edit Human	View/Edit Mouse

Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear receptor protein that in humans is encoded by the THRB gene.^[5]^[6]