TNFAIP8L2
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
TNF alpha induced protein 8 like 2 (TNFAIP8L2), also known as TIPE2, is a protein that in humans is encoded by the TNFAIP8L2 gene. It is preferentially expressed in human myeloid cell types and serves as an immune checkpoint regulator of inflammation and metabolism.[5]
| TNFAIP8L2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | TNFAIP8L2, TIPE2, TNF alpha induced protein 8 like 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 612112; MGI: 1917019; HomoloGene: 56998; GeneCards: TNFAIP8L2; OMA:TNFAIP8L2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
TNFAIP8L2 is a member of the TNFAIP8 (tumor necrosis factor-α-induced protein 8, or TIPE) family that function as transfer proteins for the second messenger lipids PIP2 and PIP3. The other three family members are TNFAIP8, TNFAIP8L1 and TNFAIP8L3.[6]
Structure
The crystal structure of TIPE2 reveals that it contains a large, hydrophobic central cavity that is poised for cofactor binding.[7]
Clinical significance
TIPE2 acts as a negative regulator of the immune system.[5][8] It is down-regulated in patients with infectious and autoimmune diseases and also acts as a tumor suppressor in several types of cancer.[9] Its knockout leads to leukocytosis and systemic inflammatory disorders in mice.[6][10]
