TOMM70

Mitochondrial import receptor subunit TOM70, also known as translocase of outer mitochondrial membrane protein 70 is a protein that in humans is encoded by the TOMM70 gene.^[5][6]

AliasesTOMM70, TOMM70A, Tom70, translocase of outer mitochondrial membrane 70

External IDsOMIM: 606081; MGI: 106295; HomoloGene: 40112; GeneCards: TOMM70; OMA:TOMM70 - orthologs

Chr.Chromosome 3 (human)^[1]

End100,401,089 bp^[1]

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TOMM70
Identifiers
Aliases	TOMM70, TOMM70A, Tom70, translocase of outer mitochondrial membrane 70
External IDs	OMIM: 606081; MGI: 106295; HomoloGene: 40112; GeneCards: TOMM70; OMA:TOMM70 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q12.2 Start 100,363,431 bp[1] End 100,401,089 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C1.1|16 34.22 cM Start 56,942,066 bp[2] End 56,977,068 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell glutes Brodmann area 23 deltoid muscle parotid gland triceps brachii muscle Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis Brodmann area 46 middle temporal gyrus Top expressed in nucleus accumbens olfactory tubercle medullary collecting duct globus pallidus cingulate gyrus amygdala dorsomedial hypothalamic nucleus Paneth cell renal corpuscle Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein transmembrane transporter activity protein binding Cellular component mitochondrial outer membrane extracellular exosome integral component of membrane mitochondrial outer membrane translocase complex membrane mitochondrion Biological process macroautophagy protein targeting to mitochondrion protein transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9868 28185 Ensembl ENSG00000154174 ENSMUSG00000022752 UniProt O94826 Q9CZW5 RefSeq (mRNA) NM_014820 NM_138599 RefSeq (protein) NP_055635 NP_613065 Location (UCSC) Chr 3: 100.36 – 100.4 Mb Chr 16: 56.94 – 56.98 Mb PubMed search [3] [4]
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The translocase of the outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. See TIM17A (MIM 605057).[supplied by OMIM]^[6]