Talk:Melatonin

The head says that the hormone elicits skin lightening in the common frog, with a wikilink to skin whitening, where it is described as "the practice of using chemical substances in an attempt to lighten the skin or provide an even skin color by reducing the melanin concentration in the skin." That specific human practice doesn't seem to be a relevant link unless I'm missing something. Understandable mistake, but remove? Moonjail (talk) 04:13, 8 April 2023 (UTC)

I was reading this too and thinking was this someone's idea of having a wind-up? (joke). How do they make the jump from the 'brain of cows' to 'lightening skins of frogs'? Was it a lab experiment? Did a cow trip and fall on a frog and the brain splat out and made the frog lighter. So many questions with that statement that seem questionable and more like April 1. (???) CaribDigita (talk) 03:27, 14 June 2024 (UTC)

this article does not state the source of melatonin used in either Rx or OTC products. If it has a synthetic source that should be under scrutiny because in the past impurities from synthetic tryptophan had caused abnormal blood cell production. Both melatonin and tryptophan have in common an indole ring . 2603:6011:F7F0:1C30:3957:B73:DB53:46D9 (talk) 03:25, 13 October 2023 (UTC)

Good morning, I would like to propose the addition of a paragraph on the use of the hormone in antineoplastic treatment. For this reason, I am gathering here the most recent sources on the subject:

• The antitumor effects of the hormone on the human body, particularly in association with adenosine, were supported in Italy by Luigi di Bella in several studies, although such efficacy remained controversial within the scientific community for years. (Source: Di Bella et al., Melatonin with adenosine solubilized in water for oncological treatment, Neuroendocrinol Lett, 2017, PubMed)

• More recent studies have shown that melatonin reduces the expression of PD-L1 in hepatocellular carcinoma cells, thereby enhancing lymphocyte activity and improving the antitumor immune response. (Source: Guo et al., Melatonin suppresses PD-L1 expression in hepatocellular carcinoma, Nature Sci Rep, 2025, nature.com)

• Other studies have investigated the anticancer mechanisms of melatonin, as it is capable of inducing apoptosis in tumor cells while inhibiting their proliferation. (Source: Wang et al.,Use of Melatonin in Cancer Treatment: Where Are We?, PMC, 2022, PubMed)

• Further evidence on the role of melatonin in cancer prevention and treatment has also been published. (Source: Li et al., Melatonin for the prevention and treatment of cancer, Oncotarget, 2017, Oncotarget) — Preceding unsigned comment added by 109.54.83.203 (talk) 13:10, 22 September 2025 (UTC)

I read this on Google. This needs to be pointed out in the article and explained. 2600:1009:B148:EDA:0:47:A697:5301 (talk) 03:06, 2 October 2025 (UTC)

There's only anecdotal evidence for this dream effect in typical users of a melatonin supplement. I searched PubMed for review articles that may have summarized dreaming effects, but there seems to be no good evidence from clinical research and no sources strong enough to discuss it in the article.

This guideline (for rapid eye movement sleep behavior disorder, i.e., not representative of typical users of melatonin) stated: "Melatonin is an intriguing option for older patients (> 50 years old) and those with neurodegenerative disease because it is only mildly sedating. Other side effects include vivid dreams and sleep fragmentation." Zefr (talk) 17:30, 2 October 2025 (UTC)

Every individual respond to medications differently; a significant amount of people does not encounter the vivid-dreaming effect.

That said, I do agree that it might warrant a mention in a passing sentence in Melatonin as a medication and supplement#Adverse effects.

Disclaimer: I suffer from vivid dreaming when taking melatonin supplements. 海盐沙冰 _{/ aka irisChronomia / Talk} 03:19, 3 October 2025 (UTC)

Hi - I added the AI-generated tag here, as the edits in 2024 by Waddie96 display several indicators of likely LLM use and thus need review for accuracy, editorializing/OR, source-to-text integrity, and the like. Gnomingstuff (talk) 22:37, 3 November 2025 (UTC)

Isn't policy that those be reverted? Damian Willard (talk) 10:47, 13 March 2026 (UTC)

I scanned the introductory paragraphs and found that they are written by a human, but were "polished" by AI, and are 97% mixed and 3% AI. Angrythewikipedian (talk) 05:37, 14 January 2026 (UTC)

However, I must clarify that this is likely NOT the only AI-generated part of the article. Angrythewikipedian (talk) 05:37, 14 January 2026 (UTC)