Talk:Neuroscience

Clinical neuroscience is a branch of neuroscience that focuses on the study of the mechanisms that underlie diseases and disorders, so I think the definition of the term Neuroscience should include something about this concept. For example, "Neuroscience is the scientific study of the nervous system... , its functions and its disorders" What do you think? Gcascas (talk) 21:32, 31 August 2022 (UTC)

Is now done. Gcascas (talk) 23:31, 29 November 2022 (UTC)

This article was the subject of a Wiki Education Foundation-supported course assignment, between 22 August 2022 and 16 December 2022. Further details are available on the course page. Student editor(s): Isabelsteffes (article contribs).

— Assignment last updated by Isabelsteffes (talk) 17:21, 7 October 2022 (UTC)

Are the neuroscience of learning and education systems, and 'neurodiversity in education' areas of research / science? Or what area do those come under? 2A0A:EF40:91C:2801:3AC0:FFD4:2029:9517 (talk) 19:20, 4 June 2024 (UTC)

Edit request: extensive neuropathology literature and ongoing study activity omitted

Hello editors. I am requesting a content-balanced update to the body of the article of the nun study Wikipedia (not the lede) to address a substantial omission. While the article thoroughly documents early epidemiologic, linguistic, and educational findings from the Nun Study, it omits both (1) a large and influential body of peer-reviewed neuropathology literature generated from this cohort over several decades and (2) evidence that the study remains an active research resource with ongoing distribution of data and biospecimens.

As currently written, the article gives the impression that neuropathologic evaluation served primarily as confirmatory background and that the study is largely historical. This is inconsistent with the published scientific record and current research use of the cohort.

Nature of the omission

Neuropathology-based investigations using Nun Study autopsy material have made foundational contributions to understanding clinicopathologic discordance between Alzheimer disease neuropathologic change and cognition, the modifying role of cerebrovascular disease in the clinical expression of dementia, hippocampal sclerosis as a major substrate of late-life cognitive impairment, TAR DNA-binding protein 43 (TDP-43) pathology as a frequent and clinically relevant co-pathology, and the concepts of cognitive resilience and resistance despite substantial neuropathology.

These findings directly informed modern mixed-dementia frameworks and consensus diagnostic criteria and are widely cited across neurology and neuropathology.

In addition, the Nun Study continues to function as an active research cohort, with standardized procedures for external investigators to request biospecimens and associated data.

Representative neuropathology literature (peer-reviewed, independent)

The following publications illustrate the breadth of neuropathologic work based on Nun Study material that is not currently reflected in the article text.

Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease. JAMA. 1997;277(10):813–817. doi:10.1001/jama.1997.03540340047033.

Riley KP, Snowdon DA, Markesbery WR. Alzheimer’s neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study. Annals of Neurology. 2002;51(5):567–577. doi:10.1002/ana.10161.

Markesbery WR, Schmitt FA, Kryscio RJ, Davis DG, Smith CD, Wekstein DR. Neuropathologic substrate of mild cognitive impairment. Archives of Neurology. 2006;63(1):38–46. doi:10.1001/archneur.63.1.38.

Nelson PT, Schmitt FA, Lin Y, et al. Hippocampal sclerosis in advanced age: clinical and pathological features. Brain. 2011;134(5):1506–1518.

Flanagan ME, Cholerton B, Latimer CS, Hemmy LS, Edland SD, Montine KS, White LR, Montine TJ. TDP-43 neuropathologic associations in the Nun Study and the Honolulu-Asia Aging Study. Journal of Alzheimer’s Disease. 2018;66(4):1549–1558. doi:10.3233/JAD-180162.

Latimer CS, Keene CD, Hemmy LS, et al. Resistance to Alzheimer disease neuropathologic changes and apparent cognitive resilience in the Nun and Honolulu-Asia Aging Studies. Journal of Neuropathology and Experimental Neurology. 2017;76(6):458–466. doi:10.1093/jnen/nlx030.

Nelson PT, Dickson DW, Trojanowski JQ, et al. Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain. 2019;142(6):1503–1527.

Montine TJ, Phelps CH, Beach TG, et al. National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease. Acta Neuropathologica. 2012;123(1):1–11. doi:10.1007/s00401-011-0910-3.

Clarke KM, Dopler M, Gonzalez A, et al. The Nun Study: Insights from 30 years of aging and dementia. Alzheimer’s and Dementia. 2025. doi:10.1002/alz.14626.

Evidence of ongoing study activity

The Nun Study remains an active research resource, with a publicly available materials and data request process for external investigators, including access to biospecimens, neuropathology data, and associated clinical information. The materials request page is available at: https://labs.uthscsa.edu/flanagan/the-nun-study-materials-request/

Requested action

I am not requesting a comprehensive rewrite. Rather, I propose adding a concise subsection (for example, “Neuropathology, clinicopathologic insights, and ongoing research use”) summarizing these findings, and citing representative high-impact neuropathology publications and the active materials request process to reflect current scientific use of the cohort.

This would improve balance, accuracy, and completeness in accordance with Wikipedia’s due-weight and medical sourcing standards.

Thank you for your consideration. ~2026-44856-3 (talk) 09:39, 21 January 2026 (UTC)