Reverse Placebo Effect DOES NOT EQUAL nocebo. Nocebo (same root as Nociception) refers to negative or harmful effects that arise from the same reasons as the placebo effect (incidentally and contrary to this article, expectation is only one of the contributing factors). A good example of this is the study by Liccardi et al. (1) where subjects given placebo but told it was a medication to which they were allergic suffered a large number of negative symptoms. One can see how this is the same effect as placebo but in this case a negative or harmful (as opposed to therapeutic) response.
This contrasts Reverse Placebo in which case expectations opposite of what are expected occur in response to a placebo. In this case, taking a placebo analgesic (in which you expect and are conditioned to pain relief), you actually feel more pain (distinctly different from taking a drug that you expect and are conditioned to hyperalgesia). See paper by Bootzin et al. (2) for evidence of the different meaning of this term.
(1) Liccardi, G., Senna, G., Russo, M., Bonadonna, P., Crivellaro, M., Dama, A., ... & Passalacqua, G. (2004). Evaluation of the nocebo effect during oral challenge in patients with adverse drug reactions. Journal of Investigational Allergology and Clinical Immunology, 14(2), 104-7.
(2) Bootzin, R. R., & Bailey, E. T. (2005). Understanding placebo, nocebo, and iatrogenic treatment effects. Journal of clinical psychology, 61(7), 871-880)
There is clearly a vastly different meaning between these two terms. Reverse Placebo should NOT redirect here. -SRoy
- I was redirected to this page when searching for "Reverse Placebo Effect." I was thinking that it was a mistake, because I wasn't thinking about the Nocebo Effect. I was interested in the notion that someone could be given an actual drug, later told that it was a placebo, and was able to reproduce results without the use of the drug.
RufioUniverse (talk) 17:02, 30 April 2009 (UTC)
- Likewise, I was looking for information on whether a potent drug can be less effective because of the patient's belief that it is a placebo or that it doesn't work. -Rrius (talk) 19:35, 17 September 2009 (UTC)
- Actually, I just last night found a reference to just such a study. I immediately thought of this article when I read it. I'll try to find a place to add the reference more or less seamlessly sometime today. The Bearded One (talk) 15:48, 21 December 2011 (UTC)
- So, given a placebo, but being told they are allergic to it, patients "suffered a large number of negative symptoms", BUT, because the effect is harmful, let's not call it a placebo?
- That's the argument?
- Seems to me that's an example of argument by euphemism.
- "No, you see, it's a NOT-placebo, a NOcebo so to speak. Totally different from the fake and imaginary effect of placebo."--109.163.140.60 (talk) 15:46, 22 September 2014 (UTC)