Talk:Olanzapine

For my latest edit on olanzapine is here a link to my twitterprofile, where Chatgbt is, according to the source I have provided, calculating the occupancy of the D4 receptors by olanzapine out in an easy to understanding way. ^[1] 2A02:3033:604:EB1E:A37B:DCFE:1B9:506 (talk) 20:56, 27 June 2025 (UTC)

I have removed the following paragraphs from the article because it is poorly written and confusing. If anyone can make sense of it and rewrite it clearly, it could potentially be added back into the article. Marbletan (talk) 14:29, 6 October 2025 (UTC)

Antipsychotics got usually categorized, in a first view, into mostly calming and sedative, and mostly having an antipsychotic (most of all namely antidelusionall) effect. Olanzapine and Clozapin, here, making an exception being heavy sedative (histaminereceptorvalue of under 2.0(knm)) and very effective for psychotic episodes at the same time.<ref>{{cite web | url=https://www.ncbi.nlm.nih.gov/books/NBK532903/ | pmid=30422498 | date=2025 | title=Olanzapine | publisher=StatPearls | vauthors = Thomas K, Saadabadi A }}</ref><ref>{{cite journal | pmid=8453823 | date=1993 | title=Pharmacokinetics and pharmacodynamics of clozapine | journal=Clinical Pharmacokinetics | volume=24 | issue=2 | pages=161–176 | doi=10.2165/00003088-199324020-00005 | vauthors = Jann MW, Grimsley SR, Gray EC, Chang WH }}</ref> Counterexamples, or neuroleptics according to this general rule would make risperidone and amisulpride being very effective against delusion and hardly sedative (with these substances also can be compared with olan- and clozapine in effectiveness against delusions), and lurasidone (and levomepromazine) at the uttermost, being very potent in sedating, yet, showing near nothing effect against acute psychosis.<ref>{{cite journal | pmid=31303314 | date=2019 | title=Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: A systematic review and network meta-analysis | journal=Lancet | volume=394 | issue=10202 | pages=939–951 | doi=10.1016/S0140-6736(19)31135-3 | pmc=6891890 | vauthors = Huhn M, Nikolakopoulou A, Schneider-Thoma J, Krause M, Samara M, Peter N, Arndt T, Bäckers L, Rothe P, Cipriani A, Davis J, Salanti G, Leucht S }}</ref><ref>{{cite web | url=https://go.drugbank.com/drugs/DB00734 | title=Risperidone }}</ref><ref>{{cite web | url=https://www.ncbi.nlm.nih.gov/books/NBK541057/ | pmid=31082101 | date=2025 | title=Lurasidone | publisher=StatPearls | vauthors = Azhar Y, Shaban K }}</ref> The ranges of the elimination halflife of both, clo- and olanzapine are in the window of an at least in theory unproblematic way of administration, when given at late, with an at least chance of getting no hangover during the next day (compared with, for example, perphenazine, where the halflife is unfavorable and a hangover more likely).<ref>{{cite web | title=Olanzapine | date=2025 | publisher=StatPearls | pmid=30422498 | url=https://www.ncbi.nlm.nih.gov/books/NBK532903/ | vauthors = Thomas K, Saadabadi A }}</ref><ref>{{cite web | title=Clozapine - How long does it stay in your system? | url=https://www.drugs.com/answers/clozapine-how-long-does-it-stay-in-your-system-85572.html }}</ref><ref>{{cite web | title=Perphenazine: Dosage, Mechanism/Onset of Action, Half-Life | url=https://www.medicine.com/drug/perphenazine/hcp }}</ref> Due to the exceptional ability, compared to clozapine, beside showing a potent occupation at the D2 receptor at the highest dose, mentioned above, to even increase this occupation at D4 receptors saturating them (90-99%)<!-- Does anyone know what this sentence means? -->, olanzapine like the infamous substances haloperidol and risperidone is considered to have a chlorpromazine equivalence of 50.<ref>{{cite journal | title=5-HT₂and D₂Receptor Occupancy of Olanzapine in Schizophrenia: A PET Investigation | journal=American Journal of Psychiatry | date=1998 | volume=155 | issue=7 | pages=921–928 | doi=10.1176/ajp.155.7.921 | pmid=9659858 | vauthors = Kapur S, Zipursky RB, Remington G, Jones C, Dasilva J, Wilson AA, Houle S }}</ref>

This article was the subject of a Wiki Education Foundation-supported course assignment, between 3 March 2026 and 17 April 2026. Further details are available on the course page. Student editor(s): Edwinazaarour (article contribs).

— Assignment last updated by Anna Palfy (talk) 17:04, 15 March 2026 (UTC)