Testicular receptor 2

The testicular receptor 2 (TR2) also known as NR2C1 (nuclear receptor subfamily 2, group C, member 1) is a protein that in humans is encoded by the NR2C1 gene.^[5][6] TR2 is a member of the nuclear receptor family of transcription factors, and is currently considered an orphan receptor. TR2 combines with 3 other transcription factors, testicular receptor 4, DNMT1, and KDM1A, to form the so called DRED complex (direct repeat erythroid determinant). This complex acts a repressor that regulates globin protein expression in the production of red blood cells, and in particular is involved in the transition from fetal to adult expression patterns.^[7]

AliasesNR2C1, TR2, Testicular receptor 2, nuclear receptor subfamily 2 group C member 1

External IDsOMIM: 601529; MGI: 1352465; HomoloGene: 55731; GeneCards: NR2C1; OMA:NR2C1 - orthologs

Chr.Chromosome 12 (human)^[1]

End95,073,628 bp^[1]

Quick facts NR2C1, Identifiers ...

NR2C1
Identifiers
Aliases	NR2C1, TR2, Testicular receptor 2, nuclear receptor subfamily 2 group C member 1
External IDs	OMIM: 601529; MGI: 1352465; HomoloGene: 55731; GeneCards: NR2C1; OMA:NR2C1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q22 Start 95,020,229 bp[1] End 95,073,628 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C2|10 48.81 cM Start 93,983,885 bp[2] End 94,033,073 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum left lobe of thyroid gland right lung tibial nerve muscle of thigh sural nerve right lobe of thyroid gland right lobe of liver gastric mucosa Top expressed in spermatid spermatocyte seminal vesicula corneal stroma otic vesicle male urethra secondary oocyte genital tubercle seminiferous tubule tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding protein homodimerization activity DNA-binding transcription factor activity zinc ion binding histone deacetylase binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding steroid hormone receptor activity DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific signaling receptor activity Cellular component PML body nucleoplasm nucleus Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated positive regulation of retinoic acid receptor signaling pathway transcription initiation from RNA polymerase II promoter negative regulation of transcription, DNA-templated steroid hormone mediated signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7181 22025 Ensembl ENSG00000120798 ENSMUSG00000005897 UniProt P13056 Q505F1 RefSeq (mRNA) NM_001032287 NM_001127362 NM_003297 NM_011629 RefSeq (protein) NP_001027458 NP_001120834 NP_003288 NP_003288.2 NP_035759 Location (UCSC) Chr 12: 95.02 – 95.07 Mb Chr 10: 93.98 – 94.03 Mb PubMed search [3] [4]
Wikidata
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